5MHL
FXIIIa in complex with the inhibitor Mi0621
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Coagulation factor XIII A chain | polymer | 738 | 84206.0 | 2 | UniProt (P00488) Pfam (PF00868) Pfam (PF01841) Pfam (PF00927) | Homo sapiens (Human) | Coagulation factor XIIIa,Protein-glutamine gamma-glutamyltransferase A chain,Transglutaminase A chain |
| 2 | C, D (K, O) | inhibitor Mi0621 | polymer | 9 | 928.2 | 2 | synthetic construct | ||
| 3 | E, F, G, N, O... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 4 | H, I, J, P, Q (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | K (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | L, M, R, S (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 7 | U, V, W (A, B, O) | water | water | 18.0 | 368 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 731 (UniProt: P00488)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | initiating methionine |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| Ile 649 | Thr 650 | engineered mutation |
| Glu 651 | Gln 652 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 170268.4 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1147.3 | |
| All* | Total formula weight | 171415.7 |
