5M7F

Human porphobilinogen deaminase in complex with DPM cofactor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Porphobilinogen deaminase	polymer	365	40285.0	2	UniProt (P08397) Pfam (PF01379) Pfam (PF03900)	Homo sapiens (Human)	PBG-D,Hydroxymethylbilane synthase,HMBS,Pre-uroporphyrinogen synthase
2	C, G (A, B)	3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid	non-polymer		420.4	2	Chemie (DPM)
3	D, E, F, H, I... (A, B)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
4	K, L (A, B)	water	water		18.0	49	Chemie (HOH)

Sequence modifications

A, B: 18 - 361 (UniProt: P08397)

PDB	External Database	Details
Met -3	-	initiating methionine
Gly -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
Ser 9	-	expression tag
Ser 10	-	expression tag
Gly 11	-	expression tag
His 12	-	expression tag
Ile 13	-	expression tag
Glu 14	-	expression tag
Gly 15	-	expression tag
Arg 16	-	expression tag
His 17	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80570.1
Non-Polymers*	Number of molecules	8
	Total formula weight	1417.2
All*	Total formula weight	81987.3

*Water molecules are not included.