5M56
Monoclinic complex structure of human protein kinase CK2 catalytic subunit (isoform CK2alpha') with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Casein kinase II subunit alpha' | polymer | 364 | 42821.8 | 2 | UniProt (P19784) Pfam (PF00069) In PDB | Homo sapiens (Human) | CK II alpha' |
2 | A, B | 4-[6,8-bis(chloranyl)-3-oxidanyl-4-oxidanylidene-chromen-2-yl]benzoic acid | non-polymer | 351.1 | 2 | Chemie (7FC) | |||
3 | A, B | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
4 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
5 | water | water | 18.0 | 378 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 350 (UniProt: P19784)
PDB | External Database | Details |
---|---|---|
Met -13 | - | initiating methionine |
Gly -12 | - | expression tag |
Ser -11 | - | expression tag |
Ser -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Ser -3 | - | expression tag |
Gln -2 | - | expression tag |
Asp -1 | - | expression tag |
Pro 0 | - | expression tag |
Gly 39 | Asp 39 | engineered mutation |
Ser 336 | Cys 336 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 85643.7 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1141.6 | |
All* | Total formula weight | 86785.2 |