5M56
Monoclinic complex structure of human protein kinase CK2 catalytic subunit (isoform CK2alpha') with the inhibitor 4'-carboxy-6,8-chloro-flavonol (FLC21)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000785 | cellular_component | chromatin |
A | 0001669 | cellular_component | acrosomal vesicle |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005956 | cellular_component | protein kinase CK2 complex |
A | 0006302 | biological_process | double-strand break repair |
A | 0006468 | biological_process | protein phosphorylation |
A | 0006915 | biological_process | apoptotic process |
A | 0007283 | biological_process | spermatogenesis |
A | 0016055 | biological_process | Wnt signaling pathway |
A | 0021987 | biological_process | cerebral cortex development |
A | 0031519 | cellular_component | PcG protein complex |
A | 0032435 | biological_process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
A | 0051726 | biological_process | regulation of cell cycle |
A | 0097421 | biological_process | liver regeneration |
A | 0106310 | molecular_function | protein serine kinase activity |
A | 1901524 | biological_process | regulation of mitophagy |
A | 1903955 | biological_process | positive regulation of protein targeting to mitochondrion |
A | 1905818 | biological_process | regulation of chromosome separation |
A | 2001234 | biological_process | negative regulation of apoptotic signaling pathway |
B | 0000785 | cellular_component | chromatin |
B | 0001669 | cellular_component | acrosomal vesicle |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004674 | molecular_function | protein serine/threonine kinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005956 | cellular_component | protein kinase CK2 complex |
B | 0006302 | biological_process | double-strand break repair |
B | 0006468 | biological_process | protein phosphorylation |
B | 0006915 | biological_process | apoptotic process |
B | 0007283 | biological_process | spermatogenesis |
B | 0016055 | biological_process | Wnt signaling pathway |
B | 0021987 | biological_process | cerebral cortex development |
B | 0031519 | cellular_component | PcG protein complex |
B | 0032435 | biological_process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
B | 0051726 | biological_process | regulation of cell cycle |
B | 0097421 | biological_process | liver regeneration |
B | 0106310 | molecular_function | protein serine kinase activity |
B | 1901524 | biological_process | regulation of mitophagy |
B | 1903955 | biological_process | positive regulation of protein targeting to mitochondrion |
B | 1905818 | biological_process | regulation of chromosome separation |
B | 2001234 | biological_process | negative regulation of apoptotic signaling pathway |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | binding site for residue 7FC A 401 |
Chain | Residue |
A | VAL67 |
A | ASP176 |
A | HOH529 |
B | ARG44 |
A | LYS69 |
A | ILE96 |
A | PHE114 |
A | GLU115 |
A | TYR116 |
A | ILE117 |
A | MET164 |
A | ILE175 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue GOL A 402 |
Chain | Residue |
A | GLN124 |
A | GLN127 |
B | LEU42 |
B | GLU53 |
B | PHE55 |
B | ILE70 |
B | HOH655 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue CL A 403 |
Chain | Residue |
A | SER278 |
A | ARG279 |
B | SER278 |
B | ARG279 |
site_id | AC4 |
Number of Residues | 16 |
Details | binding site for residue 7FC B 401 |
Chain | Residue |
A | ARG44 |
B | GLY47 |
B | ARG48 |
B | VAL67 |
B | LYS69 |
B | ILE96 |
B | PHE114 |
B | GLU115 |
B | TYR116 |
B | ILE117 |
B | MET164 |
B | ILE175 |
B | ASP176 |
B | GOL403 |
B | HOH508 |
B | HOH584 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue GOL B 402 |
Chain | Residue |
B | LYS123 |
B | PHE198 |
B | GLU231 |
B | HOH569 |
site_id | AC6 |
Number of Residues | 9 |
Details | binding site for residue GOL B 403 |
Chain | Residue |
B | GLY47 |
B | ARG48 |
B | ASN119 |
B | ASP121 |
B | PHE122 |
B | PRO160 |
B | HIS161 |
B | 7FC401 |
B | HOH646 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue GOL B 404 |
Chain | Residue |
B | PRO32 |
B | TRP34 |
B | LYS76 |
B | LYS80 |
B | LYS103 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue CL B 405 |
Chain | Residue |
B | PHE233 |
B | HIS235 |
B | ARG245 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnner..........VVVK |
Chain | Residue | Details |
A | LEU46-LYS69 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
Chain | Residue | Details |
A | ILE153-ILE165 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
Chain | Residue | Details |
A | ASP157 | |
B | ASP157 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | LEU46 | |
A | LYS69 | |
B | LEU46 | |
B | LYS69 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195 |
Chain | Residue | Details |
A | TYR13 | |
B | TYR13 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER18 | |
B | SER18 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 |
Chain | Residue | Details |
A | SER21 | |
A | SER288 | |
B | SER21 | |
B | SER288 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS97 | |
B | LYS97 |