5M54

Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	Calmodulin-regulated spectrin-associated protein 1	polymer	117	13506.6	1	UniProt (Q5T5Y3) Pfam (PF08683)	Homo sapiens (Human)
2	B, D (D, A)	Tubulin alpha chain	polymer	438	48638.8	2	UniProt (F2Z4C1) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (P81947)	Bos taurus (Bovine)
3	C, E (E, B)	Tubulin beta-2B chain	polymer	426	47809.7	2	UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953)	Bos taurus (Bovine)
4	F, J (D, A)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466)
5	G, K (D, A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG) PubChem (888)
6	H, L (E, B)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537)
7	I, M (E, B)	TAXOL	non-polymer		853.9	2	Chemie (TA1) PubChem (16757828) PubChem (16760674) PubChem (4666) PubChem (21458255) PubChem (23307219) PubChem (23412627) PubChem (23636632) PubChem (16760177) PubChem (16742549) PubChem (24848897) PubChem (24867246) PubChem (21733096) PubChem (23307242) PubChem (23307253) PubChem (23307913) PubChem (44323108) PubChem (44356961) PubChem (44403716) PubChem (24754091) PubChem (24207713) PubChem (24791027) PubChem (25200067) PubChem (42613129) PubChem (42620039) PubChem (44155032) PubChem (44276363) PubChem (46781469) PubChem (44279927) PubChem (44335735) PubChem (44291178) PubChem (44328863) PubChem (44342632) PubChem (44356895) PubChem (44378736) PubChem (49868078) PubChem (45489039) PubChem (46782671) PubChem (54259298) PubChem (71209844) PubChem (57908851) PubChem (57946364) PubChem (58803237) PubChem (53313247) PubChem (53298534) PubChem (54259297) PubChem (59844545) PubChem (54259299) PubChem (59904698) PubChem (60123443) PubChem (57489669) PubChem (57999380) PubChem (58460861) PubChem (58777027) PubChem (58798493) PubChem (58596717) PubChem (59048611) PubChem (59042813) PubChem (58877402) PubChem (60005248) PubChem (59873251) PubChem (59914794) PubChem (59919147) PubChem (60123436) PubChem (60011010) PubChem (60147315) PubChem (66795656) PubChem (70943371) PubChem (71096818) PubChem (5460441) PubChem (14060298) PubChem (176586897) PubChem (177678861) PubChem (73759783) PubChem (36314) PubChem (60915) PubChem (177409) PubChem (184492) PubChem (70801836) PubChem (70842048) PubChem (70848451) PubChem (70856170) PubChem (441276) PubChem (9854162) PubChem (73707502) PubChem (73759704) PubChem (9897470) PubChem (10033513) PubChem (10485732) PubChem (11506104) PubChem (89493063) PubChem (11828953) PubChem (89847578) PubChem (90057663) PubChem (91122402) PubChem (14060299) PubChem (14060304) PubChem (14060306) PubChem (14060309) PubChem (15983941) PubChem (91885464) PubChem (5317123) PubChem (5321715) PubChem (101920282) PubChem (5352019) PubChem (121459571) PubChem (122361554) PubChem (101598423) PubChem (6604028) PubChem (6604616) PubChem (6604814) PubChem (6713921) PubChem (6915727) PubChem (124747272) PubChem (124893098) PubChem (9875988) PubChem (126968948) PubChem (129395998) PubChem (129627423) PubChem (10748131) PubChem (132517454) PubChem (118528174) PubChem (11320430) PubChem (11354895) PubChem (134368714) PubChem (134972678) PubChem (124747271) PubChem (124747273) PubChem (124747274) PubChem (137705323) PubChem (138106885) PubChem (126761000) PubChem (140731501) PubChem (140512017) PubChem (133052515) PubChem (133640187) PubChem (146034004) PubChem (153289350) PubChem (154037993) PubChem (134715514) PubChem (155982214) PubChem (159121804) PubChem (160053861) PubChem (159716711) PubChem (160171678) PubChem (160585530) PubChem (163077211) PubChem (163077212) PubChem (163077209) PubChem (163284947) PubChem (143890766) PubChem (168322423) PubChem (152743329) PubChem (169917882) PubChem (171036874) PubChem (154828192) PubChem (144453087) PubChem (160585532) PubChem (175758871) PubChem (163077210) PubChem (163077213) PubChem (163077214) PubChem (163077215) PubChem (165084161) PubChem (166711459) PubChem (167423928) PubChem (170014955) PubChem (170362150)
8	N, O (D, A)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

D, A: 2 - 439 (UniProt: F2Z4C1)

PDB	External Database	Details
Ser 136	Leu 136	conflict
Gly 265	Ile 265	conflict
Glu 358	Gln 358	conflict

E, B: 2 - 437 (UniProt: Q6B856)

PDB	External Database	Details
Ala 57	Thr 55	conflict
Val 172	Met 170	conflict
Ala 298	Ser 296	conflict
Val 318	Ile 316	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	206403.7
Non-Polymers*	Number of molecules	8
	Total formula weight	3689.2
All*	Total formula weight	210092.9

*Water molecules are not included.