5M3O

HTRA2 A141S mutant structure

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine protease HTRA2, mitochondrial	polymer	334	36261.1	1	UniProt (O43464) Pfam (PF13365) Pfam (PF17820) In PDB	Homo sapiens (Human)	High temperature requirement protein A2,HtrA2,Omi stress-regulated endoprotease,Serine protease 25,Serine proteinase OMI
2	A	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
3		water	water		18.0	118	Chemie (HOH)

Sequence modifications

A: 134 - 458 (UniProt: O43464)

PDB	External Database	Details
Met 133	-	initiating methionine
Ser 141	Ala 141	engineered mutation
His 459	-	expression tag
Glu 460	-	expression tag
His 461	-	expression tag
His 462	-	expression tag
His 463	-	expression tag
His 464	-	expression tag
His 465	-	expression tag
His 466	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36261.1
Non-Polymers*	Number of molecules	1
	Total formula weight	195.2
All*	Total formula weight	36456.4

*Water molecules are not included.