5M3O

HTRA2 A141S mutant structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue MES A 501

Chain	Residue
A	ARG144
A	PHE172
A	LEU173
A	ARG252
A	HOH621
A	SER145
A	GLN146
A	TYR147
A	TYR147
A	ASN148
A	ASP152
A	HIS170
A	PRO171

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:11967569

Chain	Residue	Details
A	HIS198
A	ASP228
A	SER306

---