5LXB

Crystal structure of a mutant binding protein (5HTBP-AChBP) in complex with palonosetron

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Soluble acetylcholine receptor	polymer	242	27526.9	10	UniProt (Q8WSF8) Pfam (PF02931) In PDB	Aplysia californica (California sea hare)
2	A, C, D, E, F...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
3	B, C, D, E, G...	palonosetron	non-polymer		296.4	7	Chemie (7A9)
4		water	water		18.0	280	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H, I, J: -18 - 217 (UniProt: Q8WSF8)

PDB	External Database	Details
Val 41	Ala 60	conflict
Trp 53	Tyr 72	conflict
Arg 55	Gln 74	conflict
Val 136	Ala 155	conflict
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	275269.5
Non-Polymers*	Number of molecules	15
	Total formula weight	3844.5
All*	Total formula weight	279114.0

*Water molecules are not included.