5LWP
Discovery of phenoxyindazoles and phenylthioindazoles as RORg inverse agonists
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nuclear receptor ROR-gamma | polymer | 244 | 28490.1 | 1 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | B (A) | 4-[3-[2-chloranyl-6-(trifluoromethyl)phenoxy]-5-(dimethylcarbamoyl)indazol-1-yl]benzoic acid | non-polymer | 503.9 | 1 | Chemie (79U) | |||
| 3 | C (A) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A: 265 - 506 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| His 263 | - | expression tag |
| Met 264 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28490.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 503.9 | |
| All* | Total formula weight | 28993.9 |
