5LWP

Discovery of phenoxyindazoles and phenylthioindazoles as RORg inverse agonists

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue 79U A 601

Chain	Residue
A	TRP317
A	LEU483
A	GLN484
A	ALA496
A	ALA497
A	PHE498
A	LEU505
A	PHE506
A	LEU324
A	THR325
A	ILE328
A	GLN329
A	LEU353
A	LYS354
A	ALA357
A	MET358

---