5LWB

Crystal structure of human JARID1B in complex with S40650a

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Lysine-specific demethylase 5B,Lysine-specific demethylase 5B,Lysine-specific demethylase 5B	polymer	481	55457.6	1	UniProt (Q9UGL1) Pfam (PF02375) Pfam (PF02373) Pfam (PF21323) Pfam (PF02928) In PDB	Homo sapiens (Human)	Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1,Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1,Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1
2	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3	A	MANGANESE (II) ION	non-polymer		54.9	3	Chemie (MN)
4	A	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
5	A	DIMETHYL SULFOXIDE	non-polymer		78.1	5	Chemie (DMS)
6	A	5-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-7-oxidanylidene-6-propan-2-yl-6~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile	non-polymer		339.4	1	Chemie (79H)
7		water	water		18.0	153	Chemie (HOH)

Sequence modifications

A: 26 - 369 (UniProt: Q9UGL1)

PDB	External Database	Details
Ser -1	-	expression tag
Met 0	-	expression tag

A: 374 - 753 (UniProt: Q9UGL1)

PDB	External Database	Details
Gly 370	-	linker
Gly 371	-	linker
Gly 372	-	linker
Gly 373	-	linker

A: 754 - 772 (UniProt: Q9UGL1)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	55457.6
Non-Polymers*	Number of molecules	14
	Total formula weight	1208.6
All*	Total formula weight	56666.1

*Water molecules are not included.