5LV4
Crystal structure of mouse PRMT6 in complex with inhibitor LH1236
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein arginine N-methyltransferase 6 | polymer | 403 | 44597.1 | 1 | UniProt (Q6NZB1) Pfam (PF13649) In PDB | Mus musculus (House Mouse) | Histone-arginine N-methyltransferase PRMT6 |
2 | A | (2~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]amino]-2-azanyl-butanoic acid | non-polymer | 534.5 | 1 | Chemie (78K) | |||
3 | water | water | 18.0 | 331 | Chemie (HOH) |
Sequence modifications
A: 1 - 378 (UniProt: Q6NZB1)
PDB | External Database | Details |
---|---|---|
Met -24 | - | initiating methionine |
Gly -23 | - | expression tag |
Ser -22 | - | expression tag |
Ser -21 | - | expression tag |
His -20 | - | expression tag |
His -19 | - | expression tag |
His -18 | - | expression tag |
His -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
Ser -14 | - | expression tag |
Ser -13 | - | expression tag |
Gly -12 | - | expression tag |
Thr -11 | - | expression tag |
Gly -10 | - | expression tag |
Ser -9 | - | expression tag |
Gly -8 | - | expression tag |
Glu -7 | - | expression tag |
Asn -6 | - | expression tag |
Leu -5 | - | expression tag |
Tyr -4 | - | expression tag |
Phe -3 | - | expression tag |
Gln -2 | - | expression tag |
Gly -1 | - | expression tag |
His 0 | - | expression tag |
Leu 315 | Phe 315 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 44597.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 534.5 | |
All* | Total formula weight | 45131.7 |