5LV0
Structure of Human Neurolysin (E475Q) in complex with amyloid-beta 35-40 peptide product
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Neurolysin, mitochondrial | polymer | 686 | 78644.8 | 2 | UniProt (Q9BYT8) Pfam (PF01432) In PDB | Homo sapiens (Human) | Angiotensin-binding protein,Microsomal endopeptidase,MEP,Mitochondrial oligopeptidase M,Neurotensin endopeptidase |
2 | C, D | GLY-VAL-VAL amyloid 35-40 fragment | polymer | 6 | 560.7 | 2 | UniProt (by SIFTS) (P05067) In PDB | Homo sapiens | |
3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
4 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
5 | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
A, B: 15 - 681 (UniProt: Q9BYT8)
PDB | External Database | Details |
---|---|---|
Met -4 | - | initiating methionine |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
His 2 | - | expression tag |
His 3 | - | expression tag |
His 4 | - | expression tag |
His 5 | - | expression tag |
Ser 6 | - | expression tag |
Ser 7 | - | expression tag |
Gly 8 | - | expression tag |
Leu 9 | - | expression tag |
Val 10 | - | expression tag |
Pro 11 | - | expression tag |
Arg 12 | - | expression tag |
Gly 13 | - | expression tag |
Ser 14 | - | expression tag |
Gln 475 | Glu 498 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 158411.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 201.7 | |
All* | Total formula weight | 158612.7 |