5LV0

Structure of Human Neurolysin (E475Q) in complex with amyloid-beta 35-40 peptide product

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Neurolysin, mitochondrial	polymer	686	78644.8	2	UniProt (Q9BYT8) Pfam (PF01432)	Homo sapiens (Human)	Angiotensin-binding protein,Microsomal endopeptidase,MEP,Mitochondrial oligopeptidase M,Neurotensin endopeptidase
2	C, D (C, D)	GLY-VAL-VAL amyloid 35-40 fragment	polymer	6	560.7	2	UniProt (by SIFTS) (P05067)	Homo sapiens
3	E, G (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	F, H (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	I, J, K (A, B, D)	water	water		18.0	59	Chemie (HOH)

Sequence modifications

A, B: 15 - 681 (UniProt: Q9BYT8)

PDB	External Database	Details
Met -4	-	initiating methionine
Gly -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
Ser 6	-	expression tag
Ser 7	-	expression tag
Gly 8	-	expression tag
Leu 9	-	expression tag
Val 10	-	expression tag
Pro 11	-	expression tag
Arg 12	-	expression tag
Gly 13	-	expression tag
Ser 14	-	expression tag
Gln 475	Glu 498	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	158411.0
Non-Polymers*	Number of molecules	4
	Total formula weight	201.7
All*	Total formula weight	158612.7

*Water molecules are not included.