5LSS
Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Histone-lysine N-methyltransferase SETD2 | polymer | 295 | 34098.8 | 1 | UniProt (Q9BYW2) Pfam (PF17907) Pfam (PF00856) In PDB | Homo sapiens (Human) | HIF-1,Huntingtin yeast partner B,Huntingtin-interacting protein 1,HIP-1,Huntingtin-interacting protein B,Lysine N-methyltransferase 3A,SET domain-containing protein 2,hSET2,p231HBP |
2 | A | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
3 | A | THIOCYANATE ION | non-polymer | 58.1 | 1 | Chemie (SCN) | |||
4 | A | [(2~{S},5~{R})-1-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]-5-azaniumyl-6-oxidanyl-6-oxidanylidene-hexan-2-yl]-propyl-azanium | non-polymer | 425.5 | 1 | Chemie (76H) | |||
5 | water | water | 18.0 | 277 | Chemie (HOH) |
Sequence modifications
A: 1433 - 1711 (UniProt: Q9BYW2)
PDB | External Database | Details |
---|---|---|
Met 1417 | - | initiating methionine |
His 1418 | - | expression tag |
His 1419 | - | expression tag |
His 1420 | - | expression tag |
His 1421 | - | expression tag |
His 1422 | - | expression tag |
His 1423 | - | expression tag |
Ser 1424 | - | expression tag |
Ser 1425 | - | expression tag |
Gly 1426 | - | expression tag |
Arg 1427 | - | expression tag |
Glu 1428 | - | expression tag |
Asn 1429 | - | expression tag |
Leu 1430 | - | expression tag |
Tyr 1431 | - | expression tag |
Phe 1432 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34098.8 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 679.8 | |
All* | Total formula weight | 34778.6 |