5LSS

Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0042054	molecular_function	histone methyltransferase activity
A	0046975	molecular_function	histone H3K36 methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1801

Chain	Residue
A	CYS1499
A	CYS1501
A	CYS1516
A	CYS1520

---

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 1802

Chain	Residue
A	CYS1516
A	CYS1529
A	CYS1533
A	CYS1539
A	SCN1804

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1803

Chain	Residue
A	CYS1631
A	CYS1678
A	CYS1680
A	CYS1685

---

site_id	AC4
Number of Residues	8
Details	binding site for residue SCN A 1804

Chain	Residue
A	MET1497
A	CYS1499
A	ASN1522
A	CYS1529
A	SER1530
A	CYS1533
A	PRO1534
A	ZN1802

---

site_id	AC5
Number of Residues	24
Details	binding site for residue 76H A 1805

Chain	Residue
A	LYS1560
A	GLY1561
A	TRP1562
A	TYR1579
A	ILE1602
A	HIS1603
A	TYR1604
A	TYR1605
A	ARG1625
A	PHE1626
A	MET1627
A	ASN1628
A	HIS1629
A	TYR1666
A	GLN1676
A	LYS1677
A	CYS1678
A	PHE1679
A	CYS1680
A	LEU1689
A	HOH1904
A	HOH1905
A	HOH2009
A	HOH2018

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	117
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Domain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23043551","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27474439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28256625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V21","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V22","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23043551","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27474439","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28256625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H12","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V22","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---