5LPU

Crystal structure of Annexin A2 complexed with S100A4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Annexin A2	polymer	339	38613.9	2	UniProt (P07355) Pfam (PF00191) In PDB	Homo sapiens (Human)	Annexin II,Annexin-2,Calpactin I heavy chain,Calpactin-1 heavy chain,Chromobindin-8,Lipocortin II,Placental anticoagulant protein IV,PAP-IV,Protein I,p36
2	C, D	Protein S100-A4	polymer	104	12027.8	2	UniProt (P26447) Pfam (PF01023) In PDB	Homo sapiens (Human)	Calvasculin,Metastasin,Placental calcium-binding protein,Protein Mts1,S100 calcium-binding protein A4
3	A, B, C, D	CALCIUM ION	non-polymer		40.1	14	Chemie (CA)
4	A, B	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
5		water	water		18.0	288	Chemie (HOH)

Sequence modifications

A, B: 2 - 339 (UniProt: P07355)

PDB	External Database	Details
Ace 1	-	acetylation
Glu 66	Ala 66	engineered mutation

C, D: 1 - 101 (UniProt: P26447)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	101283.5
Non-Polymers*	Number of molecules	19
	Total formula weight	1021.6
All*	Total formula weight	102305.1

*Water molecules are not included.