5LP8

Crystal structure of an asymmetric dimer of the ubiquitin ligase HUWE1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	E3 ubiquitin-protein ligase HUWE1	polymer	450	52951.9	2	UniProt (Q7Z6Z7) Pfam (PF00632)	Homo sapiens (Human)	ARF-binding protein 1,ARF-BP1,HECT,UBA and WWE domain-containing protein 1,Homologous to E6AP carboxyl terminus homologous protein 9,HectH9,Large structure of UREB1,LASU1,Mcl-1 ubiquitin ligase E3,Mule,Upstream regulatory element-binding protein 1,URE-binding protein 1
2	C, D (B, A)	water	water		18.0	32	Chemie (HOH)

Sequence modifications

B, A: 3951 - 4374 (UniProt: Q7Z6Z7)

PDB	External Database	Details
Met 3925	-	initiating methionine
Lys 3926	-	expression tag
His 3927	-	expression tag
His 3928	-	expression tag
His 3929	-	expression tag
His 3930	-	expression tag
His 3931	-	expression tag
His 3932	-	expression tag
Pro 3933	-	expression tag
Met 3934	-	expression tag
Ser 3935	-	expression tag
Asp 3936	-	expression tag
Tyr 3937	-	expression tag
Asp 3938	-	expression tag
Ile 3939	-	expression tag
Pro 3940	-	expression tag
Thr 3941	-	expression tag
Thr 3942	-	expression tag
Glu 3943	-	expression tag
Asn 3944	-	expression tag
Leu 3945	-	expression tag
Tyr 3946	-	expression tag
Phe 3947	-	expression tag
Gln 3948	-	expression tag
Gly 3949	-	expression tag
Ala 3950	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	105903.9
All*	Total formula weight	105903.9

*Water molecules are not included.