5LLV

Crystal structure of DACM F87M/L110M Transthyretin mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transthyretin	polymer	128	13910.6	4	UniProt (P02766) Pfam (PF00576)	Homo sapiens (Human)	ATTR,Prealbumin,TBPA
2	E, H, I (A, C)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
3	F, G, J, K (A, B, C, D)	ACETATE ION	non-polymer		59.0	4	Chemie (ACT)
4	L, M, N, O (A, B, C, D)	water	water		18.0	182	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 127 (UniProt: P02766)

PDB	External Database	Details
Met 0	-	initiating methionine
Met 87	Phe 107	engineered mutation
Met 110	Leu 130	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	55642.5
Non-Polymers*	Number of molecules	7
	Total formula weight	342.5
All*	Total formula weight	55985.0

*Water molecules are not included.