5LLU
Structure of the thermostabilized EAAT1 cryst-II mutant in complex with L-ASP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1 | polymer | 522 | 56460.3 | 1 | UniProt (P43003) UniProt (Q15758) Pfam (PF00375) | Homo sapiens (Human) | Sodium-dependent glutamate/aspartate transporter 1,GLAST-1,Solute carrier family 1 member 3,ATB(0),Baboon M7 virus receptor,RD114/simian type D retrovirus receptor,Sodium-dependent neutral amino acid transporter type 2,Solute carrier family 1 member 5,Sodium-dependent glutamate/aspartate transporter 1,GLAST-1,Solute carrier family 1 member 3 |
| 2 | B (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 3 | C (A) | ASPARTIC ACID | non-polymer | 133.1 | 1 | Chemie (ASP) |
Sequence modifications
A: 1 - 148 (UniProt: P43003)
A: 149 - 222 (UniProt: Q15758)
A: 223 - 522 (UniProt: P43003)
| PDB | External Database | Details |
|---|---|---|
| Ser 23 | Arg 23 | conflict |
| Phe 44 | Tyr 44 | conflict |
| Arg 46 | Phe 46 | conflict |
| Leu 50 | Phe 50 | conflict |
| Leu 51 | Val 51 | conflict |
| Leu 56 | Thr 56 | conflict |
| Leu 60 | Val 60 | conflict |
| Val 62 | Thr 62 | conflict |
| Val 63 | Ile 63 | conflict |
| Leu 67 | Thr 67 | conflict |
| Pro 72 | Arg 72 | conflict |
| Leu 73 | Met 73 | conflict |
| Pro 75 | Tyr 75 | conflict |
| Ala 82 | Ser 82 | conflict |
| Lys 93 | Gln 93 | conflict |
| Ile 96 | Val 96 | conflict |
| Val 101 | Ile 101 | conflict |
| Ile 105 | Val 105 | conflict |
| Leu 108 | Met 108 | conflict |
| Ser 110 | Ala 110 | conflict |
| Ala 113 | Ser 113 | conflict |
| Arg 118 | Lys 118 | conflict |
| Leu 119 | Met 119 | conflict |
| Ser 129 | Thr 129 | conflict |
| Leu 137 | Ile 137 | conflict |
| Leu 141 | Ile 141 | conflict |
| Leu 143 | Ile 143 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 155 | Asn 163 | conflict |
| Cys 175 | Ser 183 | conflict |
| Thr 204 | Asn 212 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ile 223 | Ala 243 | conflict |
| Ile 231 | Met 251 | conflict |
| Val 232 | Cys 252 | conflict |
| Ile 235 | Phe 255 | conflict |
| Ala 236 | Val 256 | conflict |
| Leu 237 | Ile 257 | conflict |
| Lys 239 | Asn 259 | conflict |
| Gly 241 | Lys 261 | conflict |
| Leu 246 | Ala 266 | conflict |
| Val 248 | Arg 268 | conflict |
| Asp 249 | Glu 269 | conflict |
| Asn 252 | Asp 272 | conflict |
| Thr 258 | Ile 278 | conflict |
| Lys 260 | Arg 280 | conflict |
| Ile 264 | Val 284 | conflict |
| Leu 271 | Val 291 | conflict |
| Leu 287 | Met 307 | conflict |
| Glu 288 | Gly 308 | conflict |
| Leu 290 | Ile 310 | conflict |
| Gly 295 | Ala 315 | conflict |
| Met 298 | Thr 318 | conflict |
| Val 306 | Leu 326 | conflict |
| Gly 309 | Ala 329 | conflict |
| Leu 310 | Val 330 | conflict |
| Ile 316 | Leu 336 | conflict |
| Ile 320 | Val 340 | conflict |
| Phe 326 | Trp 346 | conflict |
| Ala 330 | Gly 350 | conflict |
| Ile 332 | Leu 352 | conflict |
| Ile 366 | Val 386 | conflict |
| Val 388 | Leu 408 | conflict |
| Tyr 399 | Phe 419 | conflict |
| Asp 402 | Asn 422 | conflict |
| Ala 437 | Ser 457 | conflict |
| Leu 454 | Phe 474 | conflict |
| Phe 458 | Leu 478 | conflict |
| Met 461 | Thr 481 | conflict |
| Val 462 | Thr 482 | conflict |
| Ala 468 | Ser 488 | conflict |
| Lys 480 | His 500 | conflict |
| Glu 483 | Lys 503 | conflict |
| Lys 484 | Asn 504 | conflict |
| Gln 485 | Arg 505 | conflict |
| Ala 487 | Val 507 | conflict |
| Leu 489 | Met 509 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 56460.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 156.1 | |
| All* | Total formula weight | 56616.4 |
