5LK5

Crystal structure of the globular domain of human calreticulin mutant D71K

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Calreticulin,Calreticulin	polymer	265	30160.4	10	UniProt (P27797) Pfam (PF00262)	Homo sapiens (Human)	CRP55,Calregulin,Endoplasmic reticulum resident protein 60,ERp60,HACBP,grp60,CRP55,Calregulin,Endoplasmic reticulum resident protein 60,ERp60,HACBP,grp60
2	K, L, M, N, O... (A, B, C, D, E...)	CALCIUM ION	non-polymer		40.1	10	Chemie (CA)
3	P (E)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
4	AA, BA, CA, DA, EA... (F, G, H, I, J...)	water	water		18.0	961	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H, I, J: 18 - 204 (UniProt: P27797)

PDB	External Database	Details
Asn 10	-	expression tag
Lys 11	-	expression tag
Gly 12	-	expression tag
Ser 13	-	expression tag
Ile 14	-	expression tag
Glu 15	-	expression tag
Gly 16	-	expression tag
Arg 17	-	expression tag
Lys 71	Asp 71	engineered mutation

A, B, C, D, E, F, G, H, I, J: 303 - 368 (UniProt: P27797)

PDB	External Database	Details
Gly 205	-	linker
Ser 206	-	linker
Gly 207	-	linker
Asp 302	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	301603.6
Non-Polymers*	Number of molecules	11
	Total formula weight	436.2
All*	Total formula weight	302039.8

*Water molecules are not included.