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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5LJ5

Overall structure of the yeast spliceosome immediately after branching.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1UU5 snRNA (small nuclear RNA)polymer17957444.91GenBank (1039023403)Saccharomyces cerevisiae
2EExon 1 (5' exon) of UBC4 pre-mRNApolymer165170.21Saccharomyces cerevisiae
3IIntron of UBC4 pre-mRNApolymer7624109.11GenBank (4718)Saccharomyces cerevisiae
4ZU2 snRNA (small nuclear RNA)polymer1175376267.41GenBank (536627)Saccharomyces cerevisiae
5VU6 snRNA (small nuclear RNA)polymer11235883.21GenBank (1039022925)Saccharomyces cerevisiae
6APre-mRNA-splicing factor 8polymer2413279867.51UniProt (P33334)
Pfam (PF08082)
Pfam (PF08083)
Pfam (PF10598)
Pfam (PF10597)
Pfam (PF10596)
Pfam (PF12134)
Pfam (PF08084)
In PDB		Saccharomyces cerevisiae
7BPre-mRNA-splicing helicase BRR2polymer2163246470.31UniProt (P32639)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF02889)
Pfam (PF21188)
Pfam (PF18149)
In PDB		Saccharomyces cerevisiaeProtein Snu246
8DProtein CWC16polymer27832371.11UniProt (P28320)
Pfam (PF04502)
In PDB		Saccharomyces cerevisiae
9FPre-mRNA-splicing factor CWC25polymer17920412.51UniProt (P53854)
Pfam (PF10197)
Pfam (PF12542)
In PDB		Saccharomyces cerevisiaeComplexed with CEF1 protein 25
10CPre-mRNA-splicing factor SNU114polymer1008114174.01UniProt (P36048)
Pfam (PF16004)
Pfam (PF00009)
Pfam (PF03764)
Pfam (PF00679)
In PDB		Saccharomyces cerevisiae114 kDa U5 small nuclear ribonucleoprotein component,Growth inhibitory protein 10
11GPre-mRNA-splicing factor ISY1polymer23528073.81UniProt (P21374)
Pfam (PF06246)
In PDB		Saccharomyces cerevisiaeInteractor of SYF1,PRP19-associated complex protein 30
12HCWC22polymer59169119.01UniProt (A0A162ERE7)
In PDB		Saccharomyces cerevisiae
13JPre-mRNA-splicing factor PRP46polymer45150771.31UniProt (Q12417)
Pfam (PF00400)
In PDB		Saccharomyces cerevisiaeComplexed with CEF1 protein 1,PRP nineteen-associated complex protein 50,PRP19-associated complex protein 50,Pre-mRNA-processing protein 46
14KPre-mRNA-processing protein 45polymer37942548.71UniProt (P28004)
Pfam (PF02731)
In PDB		Saccharomyces cerevisiae
15LPre-mRNA-splicing factor BUD31polymer15718484.51UniProt (P25337)
Pfam (PF01125)
In PDB		Saccharomyces cerevisiaeBud site selection protein 31,Complexed with CEF1 protein 14
16MPre-mRNA-splicing factor CWC2polymer33938486.61UniProt (Q12046)
Pfam (PF16131)
Pfam (PF00076)
In PDB		Saccharomyces cerevisiaeComplexed with CEF1 protein 2,PRP19-associated complex protein 40,Synthetic lethal with CLF1 protein 3
17NPre-mRNA-splicing factor SLT11polymer36440988.61UniProt (P38241)
Pfam (PF21369)
In PDB		Saccharomyces cerevisiaeExtracellular mutant protein 2,Synthetic lethality with U2 protein 11
18OPre-mRNA-splicing factor CEF1polymer59067837.81UniProt (Q03654)
Pfam (PF00249)
Pfam (PF11831)
In PDB		Saccharomyces cerevisiaePRP nineteen-associated complex protein 85,PRP19-associated complex protein 85
19PCWC15polymer17519970.21UniProt (A0A162GIZ3)
In PDB		Saccharomyces cerevisiae
20RPre-mRNA-splicing factor CWC21polymer13515793.61UniProt (Q03375)
Pfam (PF08312)
In PDB		Saccharomyces cerevisiaeComplexed with CEF1 protein 21
21SPre-mRNA-splicing factor CLF1polymer68782555.91UniProt (Q12309)
Pfam (PF02184)
In PDB		Saccharomyces cerevisiaeCrooked neck-like factor 1,PRP19-associated complex protein 77,Synthetic lethal with CDC40 protein 3
22TPre-mRNA-splicing factor SYF1polymer859100344.01UniProt (Q04048)
In PDB		Saccharomyces cerevisiaePRP19-associated complex protein 90,Synthetic lethal with CDC40 protein 1
23b, kSmall nuclear ribonucleoprotein-associated protein Bpolymer19622427.02UniProt (P40018)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiaesnRNP-B,Sm protein B,SmB
24d, nSmall nuclear ribonucleoprotein Sm D3polymer10111240.12UniProt (P43321)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiaeSm-D3,snRNP core protein D3
25e, pSmall nuclear ribonucleoprotein Epolymer9410385.12UniProt (Q12330)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiaesnRNP-E,Sm protein E,SmE
26f, qSmall nuclear ribonucleoprotein Fpolymer869669.92UniProt (P54999)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiaesnRNP-F,Sm protein F,SmF
27g, rSmall nuclear ribonucleoprotein Gpolymer778490.82UniProt (P40204)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiaesnRNP-G,Sm protein G,SmG
28h, lSmall nuclear ribonucleoprotein Sm D1polymer14616296.82UniProt (Q02260)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiaeSm-D1,snRNP core protein D1
29j, mSmall nuclear ribonucleoprotein Sm D2polymer11012876.12UniProt (Q06217)
Pfam (PF01423)
In PDB		Saccharomyces cerevisiaeSm-D2,snRNP core protein D2
30WU2 small nuclear ribonucleoprotein A'polymer23827232.31UniProt (Q08963)
Pfam (PF14580)
In PDB		Saccharomyces cerevisiaeU2 snRNP A',Looks exceptionally like U2A protein 1
31YU2 small nuclear ribonucleoprotein B''polymer11112850.91UniProt (P40567)
Pfam (PF13893)
In PDB		Saccharomyces cerevisiaeU2 snRNP B''
32QPre-mRNA-splicing factor ATP-dependent RNA helicase PRP16polymer1071121815.21UniProt (P15938)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF04408)
Pfam (PF21010)
Pfam (PF07717)
In PDB		Saccharomyces cerevisiae
33t, u, v, wPre-mRNA-processing factor 19polymer50356629.84UniProt (P32523)
Pfam (PF08606)
In PDB		Saccharomyces cerevisiae
34sPre-mRNA-splicing factor SNT309polymer17520741.51UniProt (Q06091)
In PDB		Saccharomyces cerevisiaePRP19-associated complex protein 25,Synergistic to PRP19 mutation protein 309
35xunknownpolymer18816017.71Saccharomyces cerevisiae
36E, VMAGNESIUM IONnon-polymer24.32Chemie (MG)
37M, N, D, LZINC IONnon-polymer65.47Chemie (ZN)
38CGUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains45
Total formula weight2375092.3
Non-Polymers*Number of molecules10
Total formula weight1029.7
All*Total formula weight2376122.0
*Water molecules are not included.

218853

PDB entries from 2024-04-24

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