Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5LJ5

Overall structure of the yeast spliceosome immediately after branching.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
A	0000386	molecular_function	second spliceosomal transesterification activity
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000389	biological_process	mRNA 3'-splice site recognition
A	0000395	biological_process	mRNA 5'-splice site recognition
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0003729	molecular_function	mRNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0005737	cellular_component	cytoplasm
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0017070	molecular_function	U6 snRNA binding
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0097157	molecular_function	pre-mRNA intronic binding
A	1990904	cellular_component	ribonucleoprotein complex
B	0000166	molecular_function	nucleotide binding
B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003676	molecular_function	nucleic acid binding
B	0003724	molecular_function	RNA helicase activity
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005681	cellular_component	spliceosomal complex
B	0005682	cellular_component	U5 snRNP
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0042802	molecular_function	identical protein binding
B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0000166	molecular_function	nucleotide binding
C	0000244	biological_process	spliceosomal tri-snRNP complex assembly
C	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
C	0000387	biological_process	spliceosomal snRNP assembly
C	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005681	cellular_component	spliceosomal complex
C	0005682	cellular_component	U5 snRNP
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0030623	molecular_function	U5 snRNA binding
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
D	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
D	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
D	0000384	molecular_function	first spliceosomal transesterification activity
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005681	cellular_component	spliceosomal complex
D	0006397	biological_process	mRNA processing
D	0008380	biological_process	RNA splicing
D	0030620	molecular_function	U2 snRNA binding
D	0046872	molecular_function	metal ion binding
D	0071006	cellular_component	U2-type catalytic step 1 spliceosome
D	0071007	cellular_component	U2-type catalytic step 2 spliceosome
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0003674	molecular_function	molecular_function
F	0005634	cellular_component	nucleus
F	0005681	cellular_component	spliceosomal complex
F	0005684	cellular_component	U2-type spliceosomal complex
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
G	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
G	0000384	molecular_function	first spliceosomal transesterification activity
G	0000389	biological_process	mRNA 3'-splice site recognition
G	0000974	cellular_component	Prp19 complex
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005681	cellular_component	spliceosomal complex
G	0005737	cellular_component	cytoplasm
G	0006397	biological_process	mRNA processing
G	0008380	biological_process	RNA splicing
G	0071006	cellular_component	U2-type catalytic step 1 spliceosome
G	0071007	cellular_component	U2-type catalytic step 2 spliceosome
G	0071013	cellular_component	catalytic step 2 spliceosome
G	0071014	cellular_component	post-mRNA release spliceosomal complex
G	0071020	cellular_component	post-spliceosomal complex
H	0003723	molecular_function	RNA binding
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0000974	cellular_component	Prp19 complex
J	0003674	molecular_function	molecular_function
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005681	cellular_component	spliceosomal complex
J	0005737	cellular_component	cytoplasm
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0071011	cellular_component	precatalytic spliceosome
J	0071013	cellular_component	catalytic step 2 spliceosome
K	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
K	0000384	molecular_function	first spliceosomal transesterification activity
K	0000386	molecular_function	second spliceosomal transesterification activity
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005681	cellular_component	spliceosomal complex
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0071006	cellular_component	U2-type catalytic step 1 spliceosome
K	0071007	cellular_component	U2-type catalytic step 2 spliceosome
K	0071014	cellular_component	post-mRNA release spliceosomal complex
L	0000282	biological_process	cellular bud site selection
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0003674	molecular_function	molecular_function
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005681	cellular_component	spliceosomal complex
L	0005686	cellular_component	U2 snRNP
L	0006397	biological_process	mRNA processing
L	0008380	biological_process	RNA splicing
M	0000387	biological_process	spliceosomal snRNP assembly
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0000974	cellular_component	Prp19 complex
M	0003676	molecular_function	nucleic acid binding
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005681	cellular_component	spliceosomal complex
M	0006397	biological_process	mRNA processing
M	0007049	biological_process	cell cycle
M	0008270	molecular_function	zinc ion binding
M	0008380	biological_process	RNA splicing
M	0017070	molecular_function	U6 snRNA binding
M	0033120	biological_process	positive regulation of RNA splicing
M	0036002	molecular_function	pre-mRNA binding
M	0045292	biological_process	mRNA cis splicing, via spliceosome
M	0045787	biological_process	positive regulation of cell cycle
M	0046872	molecular_function	metal ion binding
M	0071006	cellular_component	U2-type catalytic step 1 spliceosome
M	0071007	cellular_component	U2-type catalytic step 2 spliceosome
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0000974	cellular_component	Prp19 complex
N	0003723	molecular_function	RNA binding
N	0005634	cellular_component	nucleus
N	0005681	cellular_component	spliceosomal complex
N	0006397	biological_process	mRNA processing
N	0008380	biological_process	RNA splicing
N	0017070	molecular_function	U6 snRNA binding
N	0036002	molecular_function	pre-mRNA binding
N	0071006	cellular_component	U2-type catalytic step 1 spliceosome
N	0071007	cellular_component	U2-type catalytic step 2 spliceosome
O	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
O	0000386	molecular_function	second spliceosomal transesterification activity
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000974	cellular_component	Prp19 complex
O	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
O	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
O	0003677	molecular_function	DNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005681	cellular_component	spliceosomal complex
O	0005737	cellular_component	cytoplasm
O	0006397	biological_process	mRNA processing
O	0008380	biological_process	RNA splicing
O	0071006	cellular_component	U2-type catalytic step 1 spliceosome
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0005681	cellular_component	spliceosomal complex
Q	0000166	molecular_function	nucleotide binding
Q	0000350	biological_process	generation of catalytic spliceosome for second transesterification step
Q	0000378	biological_process	RNA exon ligation
Q	0000386	molecular_function	second spliceosomal transesterification activity
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0003676	molecular_function	nucleic acid binding
Q	0003723	molecular_function	RNA binding
Q	0003724	molecular_function	RNA helicase activity
Q	0004386	molecular_function	helicase activity
Q	0005524	molecular_function	ATP binding
Q	0005634	cellular_component	nucleus
Q	0005681	cellular_component	spliceosomal complex
Q	0006396	biological_process	RNA processing
Q	0006397	biological_process	mRNA processing
Q	0008186	molecular_function	ATP-dependent activity, acting on RNA
Q	0008380	biological_process	RNA splicing
Q	0016073	biological_process	snRNA metabolic process
Q	0016787	molecular_function	hydrolase activity
Q	0016887	molecular_function	ATP hydrolysis activity
Q	0022613	biological_process	ribonucleoprotein complex biogenesis
Q	0034458	molecular_function	3'-5' RNA helicase activity
Q	0040031	biological_process	snRNA modification
Q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Q	1990904	cellular_component	ribonucleoprotein complex
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0003674	molecular_function	molecular_function
R	0005634	cellular_component	nucleus
R	0005681	cellular_component	spliceosomal complex
R	0005684	cellular_component	U2-type spliceosomal complex
R	0005737	cellular_component	cytoplasm
R	0006397	biological_process	mRNA processing
R	0008380	biological_process	RNA splicing
S	0000245	biological_process	spliceosomal complex assembly
S	0000354	biological_process	cis assembly of pre-catalytic spliceosome
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0000785	cellular_component	chromatin
S	0000974	cellular_component	Prp19 complex
S	0003682	molecular_function	chromatin binding
S	0003688	molecular_function	DNA replication origin binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005681	cellular_component	spliceosomal complex
S	0006270	biological_process	DNA replication initiation
S	0006396	biological_process	RNA processing
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0071004	cellular_component	U2-type prespliceosome
S	0071006	cellular_component	U2-type catalytic step 1 spliceosome
S	0071007	cellular_component	U2-type catalytic step 2 spliceosome
S	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex
S	0071011	cellular_component	precatalytic spliceosome
S	0071014	cellular_component	post-mRNA release spliceosomal complex
T	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
T	0000384	molecular_function	first spliceosomal transesterification activity
T	0000386	molecular_function	second spliceosomal transesterification activity
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0000974	cellular_component	Prp19 complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005681	cellular_component	spliceosomal complex
T	0005829	cellular_component	cytosol
T	0006396	biological_process	RNA processing
T	0006397	biological_process	mRNA processing
T	0008380	biological_process	RNA splicing
T	0071004	cellular_component	U2-type prespliceosome
T	0071006	cellular_component	U2-type catalytic step 1 spliceosome
T	0071007	cellular_component	U2-type catalytic step 2 spliceosome
T	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex
T	0071014	cellular_component	post-mRNA release spliceosomal complex
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0003674	molecular_function	molecular_function
W	0005634	cellular_component	nucleus
W	0005681	cellular_component	spliceosomal complex
W	0005686	cellular_component	U2 snRNP
W	0005737	cellular_component	cytoplasm
W	0006397	biological_process	mRNA processing
W	0008380	biological_process	RNA splicing
W	0030620	molecular_function	U2 snRNA binding
W	0071004	cellular_component	U2-type prespliceosome
W	1903241	biological_process	U2-type prespliceosome assembly
Y	0000398	biological_process	mRNA splicing, via spliceosome
Y	0003676	molecular_function	nucleic acid binding
Y	0003723	molecular_function	RNA binding
Y	0003729	molecular_function	mRNA binding
Y	0005634	cellular_component	nucleus
Y	0005681	cellular_component	spliceosomal complex
Y	0005686	cellular_component	U2 snRNP
Y	0006397	biological_process	mRNA processing
Y	0008380	biological_process	RNA splicing
Y	0030620	molecular_function	U2 snRNA binding
Y	0043484	biological_process	regulation of RNA splicing
Y	0071004	cellular_component	U2-type prespliceosome
Y	1903241	biological_process	U2-type prespliceosome assembly
Y	1990904	cellular_component	ribonucleoprotein complex
b	0000243	cellular_component	commitment complex
b	0000245	biological_process	spliceosomal complex assembly
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000395	biological_process	mRNA 5'-splice site recognition
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003674	molecular_function	molecular_function
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005681	cellular_component	spliceosomal complex
b	0005682	cellular_component	U5 snRNP
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005737	cellular_component	cytoplasm
b	0006397	biological_process	mRNA processing
b	0008380	biological_process	RNA splicing
b	0032991	cellular_component	protein-containing complex
b	0036261	biological_process	7-methylguanosine cap hypermethylation
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0071001	cellular_component	U4/U6 snRNP
b	0071004	cellular_component	U2-type prespliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	1903241	biological_process	U2-type prespliceosome assembly
b	1990904	cellular_component	ribonucleoprotein complex
d	0000243	cellular_component	commitment complex
d	0000245	biological_process	spliceosomal complex assembly
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000395	biological_process	mRNA 5'-splice site recognition
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0003723	molecular_function	RNA binding
d	0003729	molecular_function	mRNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005681	cellular_component	spliceosomal complex
d	0005682	cellular_component	U5 snRNP
d	0005685	cellular_component	U1 snRNP
d	0005686	cellular_component	U2 snRNP
d	0005687	cellular_component	U4 snRNP
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0006396	biological_process	RNA processing
d	0006397	biological_process	mRNA processing
d	0008380	biological_process	RNA splicing
d	0034715	cellular_component	pICln-Sm protein complex
d	0034719	cellular_component	SMN-Sm protein complex
d	0036261	biological_process	7-methylguanosine cap hypermethylation
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0071001	cellular_component	U4/U6 snRNP
d	0071004	cellular_component	U2-type prespliceosome
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	0097525	cellular_component	spliceosomal snRNP complex
d	0097526	cellular_component	spliceosomal tri-snRNP complex
d	1903241	biological_process	U2-type prespliceosome assembly
d	1990904	cellular_component	ribonucleoprotein complex
e	0000243	cellular_component	commitment complex
e	0000245	biological_process	spliceosomal complex assembly
e	0000387	biological_process	spliceosomal snRNP assembly
e	0000395	biological_process	mRNA 5'-splice site recognition
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005681	cellular_component	spliceosomal complex
e	0005682	cellular_component	U5 snRNP
e	0005685	cellular_component	U1 snRNP
e	0005686	cellular_component	U2 snRNP
e	0005687	cellular_component	U4 snRNP
e	0005737	cellular_component	cytoplasm
e	0006397	biological_process	mRNA processing
e	0008380	biological_process	RNA splicing
e	0032991	cellular_component	protein-containing complex
e	0034715	cellular_component	pICln-Sm protein complex
e	0036261	biological_process	7-methylguanosine cap hypermethylation
e	0043229	cellular_component	intracellular organelle
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0071001	cellular_component	U4/U6 snRNP
e	0071004	cellular_component	U2-type prespliceosome
e	0071011	cellular_component	precatalytic spliceosome
e	1903241	biological_process	U2-type prespliceosome assembly
e	1990904	cellular_component	ribonucleoprotein complex
e	1990935	molecular_function	splicing factor binding
f	0000243	cellular_component	commitment complex
f	0000245	biological_process	spliceosomal complex assembly
f	0000387	biological_process	spliceosomal snRNP assembly
f	0000395	biological_process	mRNA 5'-splice site recognition
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005681	cellular_component	spliceosomal complex
f	0005682	cellular_component	U5 snRNP
f	0005685	cellular_component	U1 snRNP
f	0005686	cellular_component	U2 snRNP
f	0005687	cellular_component	U4 snRNP
f	0005737	cellular_component	cytoplasm
f	0006397	biological_process	mRNA processing
f	0008266	molecular_function	poly(U) RNA binding
f	0008380	biological_process	RNA splicing
f	0034715	cellular_component	pICln-Sm protein complex
f	0036261	biological_process	7-methylguanosine cap hypermethylation
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0071001	cellular_component	U4/U6 snRNP
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0120114	cellular_component	Sm-like protein family complex
f	1903241	biological_process	U2-type prespliceosome assembly
f	1990904	cellular_component	ribonucleoprotein complex
f	1990935	molecular_function	splicing factor binding
g	0000243	cellular_component	commitment complex
g	0000245	biological_process	spliceosomal complex assembly
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000395	biological_process	mRNA 5'-splice site recognition
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003674	molecular_function	molecular_function
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005737	cellular_component	cytoplasm
g	0006397	biological_process	mRNA processing
g	0008150	biological_process	biological_process
g	0008380	biological_process	RNA splicing
g	0032991	cellular_component	protein-containing complex
g	0034719	cellular_component	SMN-Sm protein complex
g	0036261	biological_process	7-methylguanosine cap hypermethylation
g	0043229	cellular_component	intracellular organelle
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0071001	cellular_component	U4/U6 snRNP
g	0071004	cellular_component	U2-type prespliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1903241	biological_process	U2-type prespliceosome assembly
g	1990904	cellular_component	ribonucleoprotein complex
h	0000243	cellular_component	commitment complex
h	0000245	biological_process	spliceosomal complex assembly
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000395	biological_process	mRNA 5'-splice site recognition
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003723	molecular_function	RNA binding
h	0003729	molecular_function	mRNA binding
h	0005634	cellular_component	nucleus
h	0005681	cellular_component	spliceosomal complex
h	0005682	cellular_component	U5 snRNP
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0006396	biological_process	RNA processing
h	0006397	biological_process	mRNA processing
h	0008380	biological_process	RNA splicing
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034715	cellular_component	pICln-Sm protein complex
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0071001	cellular_component	U4/U6 snRNP
h	0071004	cellular_component	U2-type prespliceosome
h	0071011	cellular_component	precatalytic spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	0097525	cellular_component	spliceosomal snRNP complex
h	0097526	cellular_component	spliceosomal tri-snRNP complex
h	1903241	biological_process	U2-type prespliceosome assembly
h	1990904	cellular_component	ribonucleoprotein complex
j	0000243	cellular_component	commitment complex
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000395	biological_process	mRNA 5'-splice site recognition
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0003674	molecular_function	molecular_function
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0006397	biological_process	mRNA processing
j	0008150	biological_process	biological_process
j	0008380	biological_process	RNA splicing
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0032991	cellular_component	protein-containing complex
j	0034715	cellular_component	pICln-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0071001	cellular_component	U4/U6 snRNP
j	0071004	cellular_component	U2-type prespliceosome
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	1903241	biological_process	U2-type prespliceosome assembly
j	1990904	cellular_component	ribonucleoprotein complex
k	0000243	cellular_component	commitment complex
k	0000245	biological_process	spliceosomal complex assembly
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000395	biological_process	mRNA 5'-splice site recognition
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003674	molecular_function	molecular_function
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005681	cellular_component	spliceosomal complex
k	0005682	cellular_component	U5 snRNP
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005687	cellular_component	U4 snRNP
k	0005737	cellular_component	cytoplasm
k	0006397	biological_process	mRNA processing
k	0008380	biological_process	RNA splicing
k	0032991	cellular_component	protein-containing complex
k	0036261	biological_process	7-methylguanosine cap hypermethylation
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0071001	cellular_component	U4/U6 snRNP
k	0071004	cellular_component	U2-type prespliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	1903241	biological_process	U2-type prespliceosome assembly
k	1990904	cellular_component	ribonucleoprotein complex
l	0000243	cellular_component	commitment complex
l	0000245	biological_process	spliceosomal complex assembly
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000395	biological_process	mRNA 5'-splice site recognition
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0003729	molecular_function	mRNA binding
l	0005634	cellular_component	nucleus
l	0005681	cellular_component	spliceosomal complex
l	0005682	cellular_component	U5 snRNP
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005687	cellular_component	U4 snRNP
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0006396	biological_process	RNA processing
l	0006397	biological_process	mRNA processing
l	0008380	biological_process	RNA splicing
l	0030532	cellular_component	small nuclear ribonucleoprotein complex
l	0034715	cellular_component	pICln-Sm protein complex
l	0034719	cellular_component	SMN-Sm protein complex
l	0036261	biological_process	7-methylguanosine cap hypermethylation
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0071001	cellular_component	U4/U6 snRNP
l	0071004	cellular_component	U2-type prespliceosome
l	0071011	cellular_component	precatalytic spliceosome
l	0071013	cellular_component	catalytic step 2 spliceosome
l	0097525	cellular_component	spliceosomal snRNP complex
l	0097526	cellular_component	spliceosomal tri-snRNP complex
l	1903241	biological_process	U2-type prespliceosome assembly
l	1990904	cellular_component	ribonucleoprotein complex
m	0000243	cellular_component	commitment complex
m	0000245	biological_process	spliceosomal complex assembly
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000395	biological_process	mRNA 5'-splice site recognition
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003674	molecular_function	molecular_function
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005681	cellular_component	spliceosomal complex
m	0005682	cellular_component	U5 snRNP
m	0005685	cellular_component	U1 snRNP
m	0005686	cellular_component	U2 snRNP
m	0005687	cellular_component	U4 snRNP
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0008150	biological_process	biological_process
m	0008380	biological_process	RNA splicing
m	0030532	cellular_component	small nuclear ribonucleoprotein complex
m	0032991	cellular_component	protein-containing complex
m	0034715	cellular_component	pICln-Sm protein complex
m	0036261	biological_process	7-methylguanosine cap hypermethylation
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0071001	cellular_component	U4/U6 snRNP
m	0071004	cellular_component	U2-type prespliceosome
m	0071011	cellular_component	precatalytic spliceosome
m	0071013	cellular_component	catalytic step 2 spliceosome
m	1903241	biological_process	U2-type prespliceosome assembly
m	1990904	cellular_component	ribonucleoprotein complex
n	0000243	cellular_component	commitment complex
n	0000245	biological_process	spliceosomal complex assembly
n	0000387	biological_process	spliceosomal snRNP assembly
n	0000395	biological_process	mRNA 5'-splice site recognition
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0003729	molecular_function	mRNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006396	biological_process	RNA processing
n	0006397	biological_process	mRNA processing
n	0008380	biological_process	RNA splicing
n	0034715	cellular_component	pICln-Sm protein complex
n	0034719	cellular_component	SMN-Sm protein complex
n	0036261	biological_process	7-methylguanosine cap hypermethylation
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0071001	cellular_component	U4/U6 snRNP
n	0071004	cellular_component	U2-type prespliceosome
n	0071011	cellular_component	precatalytic spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0097525	cellular_component	spliceosomal snRNP complex
n	0097526	cellular_component	spliceosomal tri-snRNP complex
n	1903241	biological_process	U2-type prespliceosome assembly
n	1990904	cellular_component	ribonucleoprotein complex
p	0000243	cellular_component	commitment complex
p	0000245	biological_process	spliceosomal complex assembly
p	0000387	biological_process	spliceosomal snRNP assembly
p	0000395	biological_process	mRNA 5'-splice site recognition
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0003723	molecular_function	RNA binding
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005681	cellular_component	spliceosomal complex
p	0005682	cellular_component	U5 snRNP
p	0005685	cellular_component	U1 snRNP
p	0005686	cellular_component	U2 snRNP
p	0005687	cellular_component	U4 snRNP
p	0005737	cellular_component	cytoplasm
p	0006397	biological_process	mRNA processing
p	0008380	biological_process	RNA splicing
p	0032991	cellular_component	protein-containing complex
p	0034715	cellular_component	pICln-Sm protein complex
p	0036261	biological_process	7-methylguanosine cap hypermethylation
p	0043229	cellular_component	intracellular organelle
p	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
p	0071001	cellular_component	U4/U6 snRNP
p	0071004	cellular_component	U2-type prespliceosome
p	0071011	cellular_component	precatalytic spliceosome
p	1903241	biological_process	U2-type prespliceosome assembly
p	1990904	cellular_component	ribonucleoprotein complex
p	1990935	molecular_function	splicing factor binding
q	0000243	cellular_component	commitment complex
q	0000245	biological_process	spliceosomal complex assembly
q	0000387	biological_process	spliceosomal snRNP assembly
q	0000395	biological_process	mRNA 5'-splice site recognition
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0003723	molecular_function	RNA binding
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005681	cellular_component	spliceosomal complex
q	0005682	cellular_component	U5 snRNP
q	0005685	cellular_component	U1 snRNP
q	0005686	cellular_component	U2 snRNP
q	0005687	cellular_component	U4 snRNP
q	0005737	cellular_component	cytoplasm
q	0006397	biological_process	mRNA processing
q	0008266	molecular_function	poly(U) RNA binding
q	0008380	biological_process	RNA splicing
q	0034715	cellular_component	pICln-Sm protein complex
q	0036261	biological_process	7-methylguanosine cap hypermethylation
q	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
q	0071001	cellular_component	U4/U6 snRNP
q	0071013	cellular_component	catalytic step 2 spliceosome
q	0120114	cellular_component	Sm-like protein family complex
q	1903241	biological_process	U2-type prespliceosome assembly
q	1990904	cellular_component	ribonucleoprotein complex
q	1990935	molecular_function	splicing factor binding
r	0000243	cellular_component	commitment complex
r	0000245	biological_process	spliceosomal complex assembly
r	0000387	biological_process	spliceosomal snRNP assembly
r	0000395	biological_process	mRNA 5'-splice site recognition
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0003674	molecular_function	molecular_function
r	0003723	molecular_function	RNA binding
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005681	cellular_component	spliceosomal complex
r	0005682	cellular_component	U5 snRNP
r	0005685	cellular_component	U1 snRNP
r	0005686	cellular_component	U2 snRNP
r	0005687	cellular_component	U4 snRNP
r	0005737	cellular_component	cytoplasm
r	0006397	biological_process	mRNA processing
r	0008150	biological_process	biological_process
r	0008380	biological_process	RNA splicing
r	0032991	cellular_component	protein-containing complex
r	0034719	cellular_component	SMN-Sm protein complex
r	0036261	biological_process	7-methylguanosine cap hypermethylation
r	0043229	cellular_component	intracellular organelle
r	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
r	0071001	cellular_component	U4/U6 snRNP
r	0071004	cellular_component	U2-type prespliceosome
r	0071011	cellular_component	precatalytic spliceosome
r	0071013	cellular_component	catalytic step 2 spliceosome
r	0097526	cellular_component	spliceosomal tri-snRNP complex
r	1903241	biological_process	U2-type prespliceosome assembly
r	1990904	cellular_component	ribonucleoprotein complex
s	0000384	molecular_function	first spliceosomal transesterification activity
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0000974	cellular_component	Prp19 complex
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005681	cellular_component	spliceosomal complex
s	0006397	biological_process	mRNA processing
s	0008380	biological_process	RNA splicing
s	0071006	cellular_component	U2-type catalytic step 1 spliceosome
t	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0000974	cellular_component	Prp19 complex
t	0004842	molecular_function	ubiquitin-protein transferase activity
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005681	cellular_component	spliceosomal complex
t	0005737	cellular_component	cytoplasm
t	0005739	cellular_component	mitochondrion
t	0005829	cellular_component	cytosol
t	0006281	biological_process	DNA repair
t	0006397	biological_process	mRNA processing
t	0006974	biological_process	DNA damage response
t	0008380	biological_process	RNA splicing
t	0016567	biological_process	protein ubiquitination
t	0016740	molecular_function	transferase activity
t	0042802	molecular_function	identical protein binding
t	0061630	molecular_function	ubiquitin protein ligase activity
t	0070534	biological_process	protein K63-linked ubiquitination
t	0071006	cellular_component	U2-type catalytic step 1 spliceosome
u	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
u	0000398	biological_process	mRNA splicing, via spliceosome
u	0000974	cellular_component	Prp19 complex
u	0004842	molecular_function	ubiquitin-protein transferase activity
u	0005515	molecular_function	protein binding
u	0005634	cellular_component	nucleus
u	0005681	cellular_component	spliceosomal complex
u	0005737	cellular_component	cytoplasm
u	0005739	cellular_component	mitochondrion
u	0005829	cellular_component	cytosol
u	0006281	biological_process	DNA repair
u	0006397	biological_process	mRNA processing
u	0006974	biological_process	DNA damage response
u	0008380	biological_process	RNA splicing
u	0016567	biological_process	protein ubiquitination
u	0016740	molecular_function	transferase activity
u	0042802	molecular_function	identical protein binding
u	0061630	molecular_function	ubiquitin protein ligase activity
u	0070534	biological_process	protein K63-linked ubiquitination
u	0071006	cellular_component	U2-type catalytic step 1 spliceosome
v	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
v	0000398	biological_process	mRNA splicing, via spliceosome
v	0000974	cellular_component	Prp19 complex
v	0004842	molecular_function	ubiquitin-protein transferase activity
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005681	cellular_component	spliceosomal complex
v	0005737	cellular_component	cytoplasm
v	0005739	cellular_component	mitochondrion
v	0005829	cellular_component	cytosol
v	0006281	biological_process	DNA repair
v	0006397	biological_process	mRNA processing
v	0006974	biological_process	DNA damage response
v	0008380	biological_process	RNA splicing
v	0016567	biological_process	protein ubiquitination
v	0016740	molecular_function	transferase activity
v	0042802	molecular_function	identical protein binding
v	0061630	molecular_function	ubiquitin protein ligase activity
v	0070534	biological_process	protein K63-linked ubiquitination
v	0071006	cellular_component	U2-type catalytic step 1 spliceosome
w	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
w	0000398	biological_process	mRNA splicing, via spliceosome
w	0000974	cellular_component	Prp19 complex
w	0004842	molecular_function	ubiquitin-protein transferase activity
w	0005515	molecular_function	protein binding
w	0005634	cellular_component	nucleus
w	0005681	cellular_component	spliceosomal complex
w	0005737	cellular_component	cytoplasm
w	0005739	cellular_component	mitochondrion
w	0005829	cellular_component	cytosol
w	0006281	biological_process	DNA repair
w	0006397	biological_process	mRNA processing
w	0006974	biological_process	DNA damage response
w	0008380	biological_process	RNA splicing
w	0016567	biological_process	protein ubiquitination
w	0016740	molecular_function	transferase activity
w	0042802	molecular_function	identical protein binding
w	0061630	molecular_function	ubiquitin protein ligase activity
w	0070534	biological_process	protein K63-linked ubiquitination
w	0071006	cellular_component	U2-type catalytic step 1 spliceosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG E 1001

Chain	Residue
E	G-1
V	G60
V	G78

site_id	AC2
Number of Residues	2
Details	binding site for residue MG V 201

Chain	Residue
V	G60
V	U80

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN D 1001

Chain	Residue
D	CYS51
D	CYS54
D	CYS88
D	CYS91

site_id	AC4
Number of Residues	17
Details	binding site for residue GTP C 1101

Chain	Residue
C	LEU142
C	HIS143
C	GLY145
C	LYS146
C	THR147
C	SER148
C	ARG176
C	LEU189
C	SER190
C	ALA215
C	GLY217
C	ASN268
C	LYS269
C	ARG272
C	SER315
C	THR316
C	LYS317

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN L 1000

Chain	Residue
L	CYS104
L	CYS105
L	CYS108
L	CYS148
L	ZN1001

site_id	AC6
Number of Residues	6
Details	binding site for residue ZN L 1001

Chain	Residue
L	CYS104
L	CYS122
L	CYS150
L	CYS153
L	ZN1000
L	ZN1002

site_id	AC7
Number of Residues	6
Details	binding site for residue ZN L 1002

Chain	Residue
L	CYS108
L	CYS120
L	CYS122
L	CYS145
L	CYS150
L	ZN1001

site_id	AC8
Number of Residues	5
Details	binding site for residue ZN M 1000

Chain	Residue
M	CYS73
M	CYS81
M	CYS87
M	HIS91
V	A35

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN N 401

Chain	Residue
N	CYS34
N	CYS37
N	CYS61
N	CYS64

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN N 402

Chain	Residue
N	CYS13
N	CYS16
N	CYS71
N	CYS74

site_id	AD2
Number of Residues	5
Details	binding site for Ligand VAL v 276 bound to SER G 22

Chain	Residue
G	SER22
G	ALA23
v	LYS275
v	LEU277
v	ARG278

site_id	AD3
Number of Residues	6
Details	binding site for Ligand ASP Q 473 bound to THR Q 403

Chain	Residue
Q	THR403
Q	GLN404
Q	ILE472
Q	GLU474
Q	ALA475
Q	ILE503

site_id	AD4
Number of Residues	11
Details	binding site for Di-peptide PHE Q 435 and VAL Q 873

Chain	Residue
Q	ILE433
Q	ARG434
Q	GLU436
Q	TYR869
Q	SER871
Q	LEU872
Q	ARG874
Q	ALA875
Q	ARG876
Q	ASP877
Q	ILE878

site_id	AD5
Number of Residues	12
Details	binding site for Di-peptide PHE Q 435 and ASP Q 877

Chain	Residue
Q	ILE433
Q	ARG434
Q	GLU436
Q	LEU872
Q	VAL873
Q	ARG874
Q	ALA875
Q	ARG876
Q	ILE878
Q	ARG879
Q	ASP880
Q	GLN881

site_id	AD6
Number of Residues	11
Details	binding site for Di-peptide PHE Q 435 and VAL Q 873

Chain	Residue
Q	ASP877
Q	ILE878
Q	ILE433
Q	ARG434
Q	GLU436
Q	TYR869
Q	SER871
Q	LEU872
Q	ARG874
Q	ALA875
Q	ARG876

Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ScVIIDEAHE

Chain	Residue	Details
Q	SER468-GLU477

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IATAgrDsVIKLWDM

Chain	Residue	Details
J	ILE239-MET253
J	VAL281-VAL295

site_id	PS00997
Number of Residues	23
Details	G10_1 G10 protein signature 1. LCClRCiqknEtNngstCiCRVP

Chain	Residue	Details
L	LEU103-PRO125

site_id	PS00998
Number of Residues	10
Details	G10_2 G10 protein signature 2. CvHCGCRGCA

Chain	Residue	Details
L	CYS145-ALA154

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. GINIDSLKFNELVKLM

Chain	Residue	Details
B	GLY174-MET189

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00541

Chain	Residue	Details
Q	GLY373
O	TRP84-LEU106
C	ASN268
D	CYS91

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19779198

Chain	Residue	Details
M	SER335
M	SER336

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:17330950, ECO:0007744\|PubMed:18407956, ECO:0007744\|PubMed:19779198

Chain	Residue	Details
C	THR88

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)