5LHD
Structure of glycosylated human aminopeptidase N
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Aminopeptidase N | polymer | 950 | 107963.7 | 4 | UniProt (P15144) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) | Homo sapiens (Human) | hAPN,Alanyl aminopeptidase,Aminopeptidase M,AP-M,Microsomal aminopeptidase,Myeloid plasma membrane glycoprotein CD13,gp150 |
| 2 | E, J, K, R (E, J, K, R) | beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 4 | In PDB GlyTouCan (G40894EI) | |||
| 3 | F, L, S (F, L, S) | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G89225LT) | |||
| 4 | DA, EA, FA, G, GA... (d, e, f, G, g...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 12 | In PDB GlyTouCan (G42666HT) | |||
| 5 | BA, CA, H, O, U... (b, c, H, O, U...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 6 | In PDB GlyTouCan (G15407YE) | |||
| 6 | T (T) | beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G31886NL) | |||
| 7 | AA, W (a, W) | beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-6)-[beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G67849DJ) | |||
| 8 | Y (Y) | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G36782MK) | |||
| 9 | BB, DC, EC, HA, IA... (B, D, A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 10 | CB, FC, JA, QB (B, D, A, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 11 | AB, AC, BC, CC, DB... (A, C, B, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 46 | Chemie (EDO) | |||
| 12 | LC, MC, NC, OC (A, B, C, D) | water | water | 18.0 | 665 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 36 - 967 (UniProt: P15144)
| PDB | External Database | Details |
|---|---|---|
| Tyr 18 | - | expression tag |
| Pro 19 | - | expression tag |
| Tyr 20 | - | expression tag |
| Asp 21 | - | expression tag |
| Val 22 | - | expression tag |
| Pro 23 | - | expression tag |
| Asp 24 | - | expression tag |
| Tyr 25 | - | expression tag |
| Ala 26 | - | expression tag |
| Gly 27 | - | expression tag |
| Ala 28 | - | expression tag |
| Gln 29 | - | expression tag |
| Pro 30 | - | expression tag |
| Ala 31 | - | expression tag |
| Arg 32 | - | expression tag |
| Ser 33 | - | expression tag |
| Pro 34 | - | expression tag |
| Gly 35 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 431854.9 | |
| Branched | Number of molecules | 29 |
| Total formula weight | 18306.8 | |
| Non-Polymers* | Number of molecules | 56 |
| Total formula weight | 4444.0 | |
| All* | Total formula weight | 454605.8 |
