5LGR

Crystal structure of mouse CARM1 in complex with ligand P1C3u

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Histone-arginine methyltransferase CARM1	polymer	361	40850.5	4	UniProt (Q9WVG6) Pfam (PF06325) In PDB	Mus musculus (House mouse)	Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4
2	E, F, G, H	Polyadenylate-binding protein 1	polymer	12	1273.5	4	UniProt (P11940) In PDB	Homo sapiens	Poly(A)-binding protein 1
3	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	A, B, C, D, E	1,2-ETHANEDIOL	non-polymer		62.1	6	Chemie (EDO)
5	A	1,2-DIMETHOXYETHANE	non-polymer		90.1	1	Chemie (DXE)
6	B	1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE	non-polymer		266.3	1	Chemie (PG6)
7	C	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
8	H, E, F, G	(2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol	non-polymer		277.3	4	Chemie (QVR)
9	H, E, F, G	L-PROLINAMIDE	non-polymer		114.1	4	Chemie (LPD)
10	F, H	ACETYL GROUP	non-polymer		44.1	2	Chemie (ACE)
11		water	water		18.0	765	Chemie (HOH)

Sequence modifications

A, B, C, D: 130 - 487 (UniProt: Q9WVG6)

PDB	External Database	Details
Gly 127	-	expression tag
His 128	-	expression tag
Met 129	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	168495.8
Non-Polymers*	Number of molecules	20
	Total formula weight	2584.8
All*	Total formula weight	171080.6

*Water molecules are not included.