5LGR

Crystal structure of mouse CARM1 in complex with ligand P1C3u

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0018216	biological_process	peptidyl-arginine methylation
B	0016274	molecular_function	protein-arginine N-methyltransferase activity
B	0018216	biological_process	peptidyl-arginine methylation
C	0016274	molecular_function	protein-arginine N-methyltransferase activity
C	0018216	biological_process	peptidyl-arginine methylation
D	0016274	molecular_function	protein-arginine N-methyltransferase activity
D	0018216	biological_process	peptidyl-arginine methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 501

Chain	Residue
A	ASN444
A	LYS445
A	HOH661

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 503

Chain	Residue
A	PRO409
A	THR410
A	GLU411
A	HOH610

---

site_id	AC3
Number of Residues	2
Details	binding site for residue DXE A 504

Chain	Residue
A	LEU178
A	GLN205

---

site_id	AC4
Number of Residues	1
Details	binding site for residue EDO B 501

Chain	Residue
B	HOH601

---

site_id	AC5
Number of Residues	5
Details	binding site for residue PG6 B 502

Chain	Residue
A	GLN456
A	LYS463
B	SER136
B	GLU245
B	HOH711

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO C 501

Chain	Residue
C	TRP404
C	HOH607
C	HOH645

---

site_id	AC7
Number of Residues	1
Details	binding site for residue PEG C 502

Chain	Residue
B	GLY461

---

site_id	AC8
Number of Residues	1
Details	binding site for residue EDO D 501

Chain	Residue
D	TRP404

---

site_id	AC9
Number of Residues	1
Details	binding site for residue EDO E 103

Chain	Residue
E	ALA4

---

site_id	AD1
Number of Residues	25
Details	binding site for Di-peptide QVR E 101 and ARG E 1

Chain	Residue
A	TYR150
A	PHE151
A	PHE153
A	TYR154
A	MET163
A	GLY193
A	GLU215
A	ALA216
A	GLY241
A	LYS242
A	VAL243
A	GLU244
A	GLU258
A	MET260
A	GLU267
A	MET269
A	SER272
A	HIS415
A	HOH683
E	ALA-1
E	ILE0
E	PRO2
E	ALA3
E	HOH204
E	HOH206

---

site_id	AD2
Number of Residues	10
Details	binding site for Di-peptide LPD E 102 and ALA E 4

Chain	Residue
A	ASN162
A	LEU413
A	THR414
A	HIS415
A	TYR417
E	PRO2
E	ALA3
E	EDO103
E	HOH203
E	HOH205

---

site_id	AD3
Number of Residues	7
Details	binding site for Di-peptide ACE F 101 and PHE F -7

Chain	Residue
A	PHE475
E	ALA3
F	ASN-5
F	MET-4
F	GLN-6
F	HOH201
F	HOH208

---

site_id	AD4
Number of Residues	23
Details	binding site for Di-peptide QVR F 102 and ARG F 1

Chain	Residue
B	TYR150
B	PHE151
B	PHE153
B	TYR154
B	GLN159
B	MET163
B	GLY193
B	GLU215
B	ALA216
B	LYS242
B	VAL243
B	GLU244
B	GLU258
B	MET260
B	GLU267
B	MET269
B	SER272
B	HIS415
B	HOH681
F	ILE0
F	PRO2
F	HOH205
F	HOH207

---

site_id	AD5
Number of Residues	6
Details	binding site for Di-peptide LPD F 103 and ALA F 4

Chain	Residue
B	ASN162
B	LEU413
B	HIS415
B	TYR417
F	PRO2
F	ALA3

---

site_id	AD6
Number of Residues	7
Details	binding site for Di-peptide LPD G 101 and ALA G 4

Chain	Residue
C	ASN162
C	LEU413
C	THR414
C	HIS415
C	TYR417
G	PRO2
G	ALA3

---

site_id	AD7
Number of Residues	25
Details	binding site for Di-peptide QVR G 102 and ARG G 1

Chain	Residue
C	TYR150
C	PHE151
C	PHE153
C	TYR154
C	MET163
C	GLY193
C	GLU215
C	ALA216
C	GLY241
C	LYS242
C	VAL243
C	GLU244
C	GLU258
C	MET260
C	GLU267
C	MET269
C	SER272
C	HIS415
C	HOH648
G	ALA-1
G	ILE0
G	PRO2
G	ALA3
G	HOH201
G	HOH202

---

site_id	AD8
Number of Residues	6
Details	binding site for Di-peptide ACE H 101 and PHE H -7

Chain	Residue
C	TYR477
G	ALA-1
H	GLN-6
H	MET-4
H	ASN-5
H	HOH205

---

site_id	AD9
Number of Residues	25
Details	binding site for Di-peptide QVR H 102 and ARG H 1

Chain	Residue
D	TYR150
D	PHE151
D	PHE153
D	TYR154
D	MET163
D	GLY193
D	GLU215
D	ALA216
D	GLY241
D	LYS242
D	VAL243
D	GLU244
D	GLU258
D	MET260
D	GLU267
D	MET269
D	SER272
D	HIS415
D	HOH625
D	HOH670
H	ALA-1
H	ILE0
H	PRO2
H	ALA3
H	HOH203

---

site_id	AE1
Number of Residues	7
Details	binding site for Di-peptide LPD H 103 and ALA H 4

Chain	Residue
D	ASN162
D	HIS415
D	TYR417
H	PRO2
H	ALA3
H	HOH202
H	HOH204

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1228
Details	Domain: {"description":"SAM-dependent MTase PRMT-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01015","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	132
Details	Region: {"description":"Required for nuclear translocation","evidences":[{"source":"PubMed","id":"30366907","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17882261","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19843527","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q86X55","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Omega-N-methylated arginine; by CARM1; partial","evidences":[{"source":"PubMed","id":"11850402","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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