5LGN
Thieno[3,2-b]pyrrole-5-carboxamides as Novel Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1: Compound 19
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Lysine-specific histone demethylase 1A | polymer | 670 | 74585.3 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) In PDB | Homo sapiens (Human) | BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2 |
2 | B | REST corepressor 1 | polymer | 133 | 15317.4 | 1 | UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249) In PDB | Homo sapiens (Human) | Protein CoREST |
3 | A | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | Homo sapiens (Human) | ||
4 | A | ~{N}-[3-(methoxymethyl)phenyl]-4-methyl-thieno[3,2-b]pyrrole-5-carboxamide | non-polymer | 300.4 | 1 | Chemie (6W0) |
Sequence modifications
A: 172 - 840 (UniProt: O60341)
PDB | External Database | Details |
---|---|---|
Pro 171 | - | expression tag |
Asp 371 | Thr 391 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 89902.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1085.9 | |
All* | Total formula weight | 90988.6 |