5LGN
Thieno[3,2-b]pyrrole-5-carboxamides as Novel Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1: Compound 19
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific histone demethylase 1A | polymer | 670 | 74585.3 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | Homo sapiens (Human) | BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2 |
| 2 | B (B) | REST corepressor 1 | polymer | 133 | 15317.4 | 1 | UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249) | Homo sapiens (Human) | Protein CoREST |
| 3 | C (A) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | Homo sapiens (Human) | ||
| 4 | D (A) | ~{N}-[3-(methoxymethyl)phenyl]-4-methyl-thieno[3,2-b]pyrrole-5-carboxamide | non-polymer | 300.4 | 1 | Chemie (6W0) |
Sequence modifications
A: 172 - 840 (UniProt: O60341)
| PDB | External Database | Details |
|---|---|---|
| Pro 171 | - | expression tag |
| Asp 371 | Thr 391 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 89902.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1085.9 | |
| All* | Total formula weight | 90988.6 |
