5LGN
Thieno[3,2-b]pyrrole-5-carboxamides as Novel Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1: Compound 19
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | binding site for residue FAD A 901 |
| Chain | Residue |
| A | GLY285 |
| A | GLY315 |
| A | ARG316 |
| A | VAL317 |
| A | LEU329 |
| A | GLY330 |
| A | ALA331 |
| A | MET332 |
| A | VAL333 |
| A | THR592 |
| A | VAL594 |
| A | GLY287 |
| A | THR628 |
| A | LEU629 |
| A | PRO630 |
| A | TRP755 |
| A | TRP760 |
| A | SER764 |
| A | TYR765 |
| A | GLY804 |
| A | GLU805 |
| A | THR814 |
| A | VAL288 |
| A | VAL815 |
| A | ALA818 |
| A | 6W0902 |
| A | SER289 |
| A | LEU307 |
| A | GLU308 |
| A | ALA309 |
| A | ARG310 |
| A | GLY314 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue 6W0 A 902 |
| Chain | Residue |
| A | THR335 |
| A | GLN358 |
| A | TRP699 |
| A | TYR765 |
| A | ALA813 |
| A | FAD901 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0007744|PDB:2DW4, ECO:0007744|PDB:2H94, ECO:0007744|PDB:2HKO, ECO:0007744|PDB:2IW5, ECO:0007744|PDB:2V1D, ECO:0007744|PDB:2X0L, ECO:0007744|PDB:2XAF, ECO:0007744|PDB:2XAG, ECO:0007744|PDB:2XAH, ECO:0007744|PDB:2XAJ, ECO:0007744|PDB:2XAQ, ECO:0007744|PDB:2XAS, ECO:0007744|PDB:2Y48, ECO:0007744|PDB:3ZMS, ECO:0007744|PDB:3ZMT, ECO:0007744|PDB:3ZMU, ECO:0007744|PDB:3ZMV, ECO:0007744|PDB:3ZMZ, ECO:0007744|PDB:3ZN0, ECO:0007744|PDB:3ZN1 |
| Chain | Residue | Details |
| A | ARG269 | |
| A | VAL288 | |
| A | GLY290 | |
| A | GLN296 | |
| A | ARG312 | |
| A | GLU805 | |
| A | THR814 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER615 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | ILE829 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS446 | |
| A | LYS473 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:25018020 |
| Chain | Residue | Details |
| A | LYS507 |
