5LF0
Human 20S proteasome complex with Epoxomicin at 2.4 Angstrom
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (A, O) | Proteasome subunit alpha type-2 | polymer | 234 | 25927.5 | 2 | UniProt (P25787) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3 |
| 2 | B, P (B, P) | Proteasome subunit alpha type-4 | polymer | 261 | 29525.8 | 2 | UniProt (P25789) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L |
| 3 | C, Q (C, Q) | Proteasome subunit alpha type-7 | polymer | 248 | 27986.9 | 2 | UniProt (O14818) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Proteasome subunit RC6-1,Proteasome subunit XAPC7 |
| 4 | D, R (D, R) | Proteasome subunit alpha type-5 | polymer | 241 | 26436.0 | 2 | UniProt (P28066) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain |
| 5 | E, S (E, S) | Proteasome subunit alpha type-1 | polymer | 263 | 29720.8 | 2 | UniProt (P25786) Pfam (PF00227) Pfam (PF10584) | Homo sapiens (Human) | 30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain |
| 6 | F, T (F, T) | Proteasome subunit alpha type-3 | polymer | 255 | 28469.3 | 2 | UniProt (P25788) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8 |
| 7 | G, U (G, U) | Proteasome subunit alpha type-6 | polymer | 246 | 27739.8 | 2 | UniProt (P60900) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (Human) | 27 kDa prosomal protein,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain |
| 8 | H, V (H, V) | Proteasome subunit beta type-7 | polymer | 234 | 25322.0 | 2 | UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) | Homo sapiens (Human) | Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z |
| 9 | I, W (I, W) | Proteasome subunit beta type-3 | polymer | 205 | 22972.9 | 2 | UniProt (P49720) Pfam (PF00227) | Homo sapiens (Human) | Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain |
| 10 | J, X (J, X) | Proteasome subunit beta type-2 | polymer | 201 | 22989.4 | 2 | UniProt (P49721) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I |
| 11 | K, Y (K, Y) | Proteasome subunit beta type-5 | polymer | 204 | 22484.4 | 2 | UniProt (P28074) Pfam (PF00227) | Homo sapiens (Human) | Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X |
| 12 | L, Z (L, Z) | Proteasome subunit beta type-1 | polymer | 213 | 23579.0 | 2 | UniProt (P20618) Pfam (PF00227) | Homo sapiens (Human) | Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain |
| 13 | AA, M (M, a) | Proteasome subunit beta type-4 | polymer | 219 | 24414.7 | 2 | UniProt (P28070) Pfam (PF00227) | Homo sapiens (Human) | 26 kDa prosomal protein,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3 |
| 14 | BA, N (N, b) | Proteasome subunit beta type-6 | polymer | 205 | 21921.8 | 2 | UniProt (P28072) Pfam (PF00227) | Homo sapiens (Human) | Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y |
| 15 | CA, DA, EA, FA, GA... (c, d, e, f, g...) | EPOXOMICIN (peptide inhibitor) | polymer | 5 | 542.8 | 6 | synthetic construct | ||
| 16 | AC, BB, BC, BD, CC... (O, H, a, P, Q...) | CHLORIDE ION | non-polymer | 35.5 | 58 | Chemie (CL) | |||
| 17 | AD, KD, LC, OB, XB... (Z, b, U, L, N...) | POTASSIUM ION | non-polymer | 39.1 | 6 | Chemie (K) | |||
| 18 | AB, DB, GB, HB, MC... (H, I, J, K, V...) | MAGNESIUM ION | non-polymer | 24.3 | 10 | Chemie (MG) | |||
| 19 | CB, ED, FB, JD, MB... (H, a, I, b, K...) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 9 | Chemie (1PE) | |||
| 20 | AE, BE, CE, DE, EE... (N, O, P, Q, R...) | water | water | 18.0 | 3173 | Chemie (HOH) |
Sequence modifications
E, S: 1 - 263 (UniProt: P25786)
G, U: 1 - 246 (UniProt: P60900)
J, X: 1 - 201 (UniProt: P49721)
| PDB | External Database | Details |
|---|---|---|
| 6v1 148 | Cys 148 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| 6v1 47 | Cys 47 | modified residue |
| 6v1 161 | Cys 161 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| 6v1 91 | Cys 91 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 34 |
| Total formula weight | 722237.0 | |
| Non-Polymers* | Number of molecules | 83 |
| Total formula weight | 4678.4 | |
| All* | Total formula weight | 726915.5 |
