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5LC5

Structure of mammalian respiratory Complex I, class2

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
NADH-ubiquinone oxidoreductase chain 3polymer11112510.91UniProt (P03898)
Pfam (PF00507)
Bos taurus (Bovine)NADH dehydrogenase subunit 3
2B
(B)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialpolymer14716625.51UniProt (P42026)
Pfam (PF01058)
Bos taurus (Bovine)Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit,PSST subunit
3C
(C)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialpolymer20624202.41UniProt (P23709)
Pfam (PF00329)
Bos taurus (Bovine)Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit
4D
(D)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialpolymer42648693.81UniProt (P17694)
Pfam (PF00346)
Bos taurus (Bovine)Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit
5E
(E)
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialpolymer24927341.51UniProt (P04394)
Pfam (PF01257)
Bos taurus (Bovine)NADH dehydrogenase subunit II,NADH-ubiquinone oxidoreductase 24 kDa subunit
6F
(F)
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialpolymer46450718.81UniProt (P25708)
Pfam (PF01512)
Pfam (PF22461)
Pfam (PF10589)
Bos taurus (Bovine)Complex I-51kD,CI-51kD,NADH dehydrogenase flavoprotein 1,NADH-ubiquinone oxidoreductase 51 kDa subunit
7G
(G)
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial,NADH-ubiquinone oxidoreductase 75 kDa subunit, NDUFS1polymer71566442.31UniProt (P15690)
Pfam (PF10588)
Pfam (PF22117)
Pfam (PF00111)
Bos taurus (Bovine)Complex I-75kD,CI-75kD,Complex I-75kD,CI-75kD,Complex I-75kD,CI-75kD,Complex I-75kD,CI-75kD
8H
(H)
NADH-ubiquinone oxidoreductase chain 1polymer31335084.11UniProt (P03887)
Pfam (PF00146)
Bos taurus (Bovine)NADH dehydrogenase subunit 1
9I
(I)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialpolymer17620219.91UniProt (P42028)
Pfam (PF12838)
Bos taurus (Bovine)Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit,TYKY subunit
10J
(J)
NADH-ubiquinone oxidoreductase chain 6polymer17118622.91UniProt (P03924)
Pfam (PF00499)
Bos taurus (Bovine)NADH dehydrogenase subunit 6
11K
(K)
NADH-ubiquinone oxidoreductase chain 4Lpolymer9510437.71UniProt (P03902)
Pfam (PF00420)
Bos taurus (Bovine)NADH dehydrogenase subunit 4L
12L
(L)
NADH-ubiquinone oxidoreductase chain 5polymer60468067.61UniProt (P03920)
Pfam (PF00662)
Pfam (PF00361)
Pfam (PF06455)
Bos taurus (Bovine)NADH dehydrogenase subunit 5
13M
(M)
NADH-ubiquinone oxidoreductase chain 4polymer45751886.41UniProt (P03910)
Pfam (PF01059)
Pfam (PF00361)
Bos taurus (Bovine)NADH dehydrogenase subunit 4
14N
(N)
NADH-ubiquinone oxidoreductase chain 2polymer34438901.51UniProt (P03892)
Pfam (PF00361)
Pfam (PF06444)
Bos taurus (Bovine)NADH dehydrogenase subunit 2
15O
(O)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, NDUFA10,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialpolymer31434014.21UniProt (P34942)
Pfam (PF01712)
Bos taurus (Bovine)Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit,Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit,Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit
16P
(P)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialpolymer33528528.01Bos taurus (Bovine)Complex I-39kD,CI-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit
17Q
(Q)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialpolymer1139634.91Bos taurus (Bovine)Complex I-18 kDa,CI-18 kDa,Complex I-AQDQ,CI-AQDQ,NADH-ubiquinone oxidoreductase 18 kDa subunit
18R
(R)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial,NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialpolymer898316.91UniProt (P23934)
Pfam (PF10276)
Bos taurus (Bovine)Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit,Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit,Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit,Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit
19S
(S)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2polymer809270.61UniProt (Q02370)
Pfam (PF05047)
Bos taurus (Bovine)Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit
20T
(T)
Acyl carrier protein, mitochondrialpolymer758672.91UniProt (P52505)
Pfam (PF00550)
Bos taurus (Bovine)ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit
21U
(U)
Acyl carrier protein, mitochondrialpolymer859846.31UniProt (P52505)
Pfam (PF00550)
Bos taurus (Bovine)ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit
22V
(V)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5polymer11613334.61UniProt (P23935)
Pfam (PF04716)
Bos taurus (Bovine)Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit
23W
(W)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6polymer12815083.51UniProt (Q02366)
Pfam (PF13233)
Bos taurus (Bovine)Complex I-B14,CI-B14,NADH-ubiquinone oxidoreductase B14 subunit
24X
(X)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8polymer16918115.21UniProt (P42029)
Pfam (PF06747)
Bos taurus (Bovine)Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit,Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit,Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit,Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit
25Y
(Y)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11polymer13814412.51UniProt (Q8HXG6)
Pfam (PF02466)
Bos taurus (Bovine)Complex I-B14.7,CI-B14.7,NADH-ubiquinone oxidoreductase subunit B14.7
26Z
(Z)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13polymer13814135.91UniProt (Q95KV7)
Pfam (PF06212)
Bos taurus (Bovine)Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit,Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit,Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit,Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit,Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit,Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit,Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit
27AA
(a)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1polymer708117.41UniProt (Q02377)
Pfam (PF15879)
Bos taurus (Bovine)Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit
28BA
(b)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3,NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3polymer807860.51UniProt (Q02371)
Pfam (PF14987)
Bos taurus (Bovine)Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit,Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit,Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit
29CA
(c)
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialpolymer768796.21UniProt (Q02376)
Pfam (PF15088)
Bos taurus (Bovine)Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit
30DA
(d)
NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2,NADH dehydrogenase [ubiquinone] 1 subunit C2polymer11411988.31UniProt (Q02827)
Pfam (PF06374)
Bos taurus (Bovine)Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b,Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b,Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b,Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b,Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b,Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b,Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b
31EA
(e)
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5polymer10612694.71UniProt (Q02379)
Pfam (PF10200)
Bos taurus (Bovine)Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit
32FA
(f)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1polymer576978.11UniProt (Q02378)
Pfam (PF08040)
Bos taurus (Bovine)Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit
33GA
(g)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrialpolymer15417594.91UniProt (Q8HXG5)
Pfam (PF10183)
Bos taurus (Bovine)Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit
34HA
(h)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialpolymer18618069.91UniProt (Q02380)
Pfam (PF09781)
Bos taurus (Bovine)Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit,Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit,Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit,Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit
35IA
(i)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6polymer12111637.01UniProt (Q02367)Bos taurus (Bovine)Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit,Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit,Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit,Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit
36JA
(j)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, NDUFB2polymer524443.51Bos taurus (Bovine)
37KA
(k)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3, NDUFB3polymer746315.81Bos taurus (Bovine)
38LA
(l)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, NDUFB8polymer11810060.41Bos taurus (Bovine)
39MA
(m)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4polymer11813415.51UniProt (P48305)
Pfam (PF07225)
Bos taurus (Bovine)Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit,Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit,Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit,Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit
40NA
(n)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9polymer16619246.11UniProt (Q02369)
Pfam (PF05347)
Bos taurus (Bovine)Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit,Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit,Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit,Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit
41OA
(o)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7polymer587583.91UniProt (Q02368)
Pfam (PF05676)
Bos taurus (Bovine)Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit
42PA
(p)
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10,NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10, NDUFB10polymer16916906.91UniProt (Q02373)
Pfam (PF10249)
Bos taurus (Bovine)Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit,Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit,Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit,Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit,Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit,Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit,Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit
43QA
(q)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12polymer13816309.51UniProt (O97725)
Pfam (PF05071)
Bos taurus (Bovine)Complex I-B17.2,CIB17.2,NADH-ubiquinone oxidoreductase subunit B17.2
44RA
(r)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, NDUFA7polymer877422.11Bos taurus (Bovine)
45SA
(s)
NADH dehydrogenase [ubiquinone] flavoprotein 3, NDUFV3polymer352996.71Bos taurus (Bovine)
46AB, BB, TA, WA, XA...
(I, B, F, G)
IRON/SULFUR CLUSTERnon-polymer351.66Chemie (SF4)
47UA, ZA
(E, G)
FE2/S2 (INORGANIC) CLUSTERnon-polymer175.82Chemie (FES)
48VA
(F)
FLAVIN MONONUCLEOTIDEnon-polymer456.31Chemie (FMN)
49CB
(P)
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer743.41Chemie (NAP)
50DB
(R)
ZINC IONnon-polymer65.41Chemie (ZN)
Sequence modifications
D: 5 - 430 (UniProt: P17694)
PDBExternal DatabaseDetails
Arg 129Gln 162conflict
G: -22 - 209 (UniProt: P15690)
G: 210 - 692 (PDB: 5LC5)
O: 5 - 90 (PDB: 5LC5)
O: 91 - 318 (UniProt: P34942)
R: 5 - 58 (PDB: 5LC5)
R: 59 - 93 (UniProt: P23934)
X: 0 - 113 (UniProt: P42029)
X: 114 - 168 (PDB: 5LC5)
Z: 5 - 30 (PDB: 5LC5)
Z: 31 - 99 (UniProt: Q95KV7)
Z: 100 - 142 (PDB: 5LC5)
b: 1 - 45 (UniProt: Q02371)
b: 46 - 80 (PDB: 5LC5)
d: 3 - 28 (PDB: 5LC5)
d: 29 - 97 (UniProt: Q02827)
d: 98 - 116 (PDB: 5LC5)
h: -45 - 45 (UniProt: Q02380)
h: 46 - 140 (PDB: 5LC5)
i: 0 - 32 (UniProt: Q02367)
i: 40 - 127 (PDB: 5LC5)
m: 11 - 31 (PDB: 5LC5)
m: 32 - 128 (UniProt: P48305)
n: 10 - 136 (UniProt: Q02369)
n: 137 - 175 (PDB: 5LC5)
p: 4 - 75 (PDB: 5LC5)
p: 76 - 142 (UniProt: Q02373)
p: 143 - 172 (PDB: 5LC5)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains45
Total formula weight881558.3
Non-Polymers*Number of molecules11
Total formula weight3726.6
All*Total formula weight885285.0
*Water molecules are not included.

226707

PDB entries from 2024-10-30

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