5LAW
Novel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 14
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | E3 ubiquitin-protein ligase Mdm2 | polymer | 94 | 11011.9 | 1 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2 |
| 2 | A | 2-[(3~{S},3'~{a}~{S},6'~{S},6'~{a}~{S})-6-chloranyl-6'-(3-chlorophenyl)-4'-(cyclopropylmethyl)-2-oxidanylidene-spiro[1~{H}-indole-3,5'-3,3~{a},6,6~{a}-tetrahydro-2~{H}-pyrrolo[3,2-b]pyrrole]-1'-yl]ethanoic acid | non-polymer | 486.4 | 1 | Chemie (6SJ) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 43 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11011.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 774.6 | |
| All* | Total formula weight | 11786.5 |
