5LAW

Novel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 14

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 6SJ A 201

Chain	Residue
A	LEU54
A	SO4202
A	HOH317
A	ILE61
A	TYR67
A	PHE86
A	VAL93
A	LYS94
A	HIS96
A	ARG97
A	ILE99

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site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 202

Chain	Residue
A	ARG97
A	6SJ201
A	HOH326

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site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 A 203

Chain	Residue
A	GLN18
A	LYS94
A	GLU95
A	HIS96
A	ARG97
A	LYS98
A	HOH332

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site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 204

Chain	Residue
A	PRO20
A	ALA21
A	LYS51
A	LYS51
A	HOH309
A	HOH319

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