5LAT
HIF prolyl hydroxylase 2 (PHD2/EGLN1) P317R variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Egl nine homolog 1 | polymer | 252 | 28157.0 | 1 | UniProt (Q9GZT9) Pfam (PF13640) In PDB | Homo sapiens (Human) | Hypoxia-inducible factor prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20 |
2 | A | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
3 | A | N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE | non-polymer | 280.7 | 1 | Chemie (UN9) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | A | BICARBONATE ION | non-polymer | 61.0 | 1 | Chemie (BCT) | |||
6 | water | water | 18.0 | 186 | Chemie (HOH) |
Sequence modifications
A: 181 - 426 (UniProt: Q9GZT9)
PDB | External Database | Details |
---|---|---|
Gly 175 | - | expression tag |
Ser 176 | - | expression tag |
His 177 | - | expression tag |
Met 178 | - | expression tag |
Ala 179 | - | expression tag |
Ser 180 | - | expression tag |
Arg 317 | Pro 317 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 28157.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 488.7 | |
All* | Total formula weight | 28645.7 |