5LAT
HIF prolyl hydroxylase 2 (PHD2/EGLN1) P317R variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue MN A 501 |
Chain | Residue |
A | HIS313 |
A | ASP315 |
A | HIS374 |
A | UN9502 |
A | HOH623 |
site_id | AC2 |
Number of Residues | 15 |
Details | binding site for residue UN9 A 502 |
Chain | Residue |
A | HIS313 |
A | ASP315 |
A | TYR329 |
A | LEU343 |
A | HIS374 |
A | VAL376 |
A | ARG383 |
A | ARG398 |
A | MN501 |
A | HOH620 |
A | HOH623 |
A | ASP254 |
A | MET299 |
A | TYR303 |
A | TYR310 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue GOL A 503 |
Chain | Residue |
A | GLN243 |
A | ASP250 |
A | GLY288 |
A | SER289 |
A | TYR290 |
A | TRP367 |
A | ARG371 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue BCT A 504 |
Chain | Residue |
A | ARG312 |
A | PRO373 |
A | HOH604 |
A | HOH605 |
A | HOH612 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16782814, ECO:0000269|PubMed:19604478, ECO:0000269|PubMed:28594552, ECO:0007744|PDB:2G19, ECO:0007744|PDB:3HQU, ECO:0007744|PDB:5V18 |
Chain | Residue | Details |
A | HIS313 | |
A | ASP315 | |
A | HIS374 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000305|PubMed:19604478 |
Chain | Residue | Details |
A | ARG383 |
site_id | SWS_FT_FI3 |
Number of Residues | 5 |
Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:21601578 |
Chain | Residue | Details |
A | CYS201 | |
A | CYS208 | |
A | CYS302 | |
A | CYS323 | |
A | CYS326 |