5L8A
Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Peroxin 14 | polymer | 69 | 7883.1 | 4 | UniProt (Q8IEW2) Pfam (PF04695) | Trypanosoma brucei brucei | |
| 2 | E, G, H, J (A, B, C, D) | 1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-~{N}-(phenylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide | non-polymer | 470.6 | 4 | Chemie (6RB) | |||
| 3 | F (A) | GLYCINE | non-polymer | 75.1 | 1 | Chemie (GLY) | |||
| 4 | I (C) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | K (D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 276 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 66 (UniProt: Q8IEW2)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Met 0 | - | expression tag |
| Trp 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 31532.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2042.4 | |
| All* | Total formula weight | 33574.7 |
