5L8A

Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005778	cellular_component	peroxisomal membrane
A	0016560	biological_process	protein import into peroxisome matrix, docking
B	0005778	cellular_component	peroxisomal membrane
B	0016560	biological_process	protein import into peroxisome matrix, docking
C	0005778	cellular_component	peroxisomal membrane
C	0016560	biological_process	protein import into peroxisome matrix, docking
D	0005778	cellular_component	peroxisomal membrane
D	0016560	biological_process	protein import into peroxisome matrix, docking

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 6RB A 101

Chain	Residue
A	ASN13
B	6RB101
A	GLU16
A	PHE17
A	ARG22
A	THR26
A	PHE34
A	LEU35
A	HOH231
B	HIS33

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site_id	AC2
Number of Residues	8
Details	binding site for residue GLY A 102

Chain	Residue
A	PRO27
A	THR28
A	SER29
A	HOH201
A	HOH206
A	HOH233
C	THR28
C	LYS56

---

site_id	AC3
Number of Residues	10
Details	binding site for residue 6RB B 101

Chain	Residue
A	HIS33
A	PHE34
A	6RB101
B	ASN13
B	PHE17
B	ARG22
B	THR26
B	PHE34
B	LYS38
B	HOH215

---

site_id	AC4
Number of Residues	12
Details	binding site for residue 6RB C 101

Chain	Residue
C	ASN13
C	GLU16
C	PHE17
C	ARG22
C	THR26
C	SER30
C	PHE34
C	LEU35
C	LYS38
C	HOH224
D	HIS33
D	6RB101

---

site_id	AC5
Number of Residues	5
Details	binding site for residue NA C 102

Chain	Residue
C	SER29
C	SER30
C	HOH233
C	HOH241
D	HOH202

---

site_id	AC6
Number of Residues	14
Details	binding site for residue 6RB D 101

Chain	Residue
C	SER30
C	HIS33
C	6RB101
D	ASN13
D	GLU16
D	PHE17
D	ASP20
D	ARG22
D	THR26
D	SER30
D	PHE34
D	LEU35
D	LYS38
D	HOH230

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO D 102

Chain	Residue
D	LYS36
D	LEU40
D	SER41
D	ALA42
D	HOH208

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