5L87
Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peroxin 14 | polymer | 69 | 7883.1 | 1 | UniProt (Q8IEW2) Pfam (PF04695) | Trypanosoma brucei brucei | |
| 2 | B (A) | 5-(1~{H}-indol-3-ylmethyl)-1-methyl-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide | non-polymer | 449.5 | 1 | Chemie (6RD) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A: 2 - 66 (UniProt: Q8IEW2)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Met 0 | - | expression tag |
| Trp 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 7883.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 511.6 | |
| All* | Total formula weight | 8394.7 |
