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5L87

Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1APeroxin 14polymer697883.11UniProt (Q8IEW2)
Pfam (PF04695)
In PDB
Trypanosoma brucei brucei
2A5-(1~{H}-indol-3-ylmethyl)-1-methyl-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamidenon-polymer449.51Chemie (6RD)
3A1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
4waterwater18.0133Chemie (HOH)
Sequence modifications
A: 2 - 66 (UniProt: Q8IEW2)
PDBExternal DatabaseDetails
Gly -2-expression tag
Ala -1-expression tag
Met 0-expression tag
Trp 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight7883.1
Non-Polymers*Number of molecules2
Total formula weight511.6
All*Total formula weight8394.7
*Water molecules are not included.

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PDB entries from 2024-03-27

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