5L6P
EphB3 kinase domain covalently bound to an irreversible inhibitor (compound 6)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Ephrin type-B receptor 3 | polymer | 298 | 33765.7 | 1 | UniProt (P54753) Pfam (PF07714) | Homo sapiens (Human) | EPH-like tyrosine kinase 2,EPH-like kinase 2,Embryonic kinase 2,hEK2,Tyrosine-protein kinase TYRO6 |
| 2 | B (A) | ~{N}-(4-phenylazanylquinazolin-7-yl)ethanamide | non-polymer | 278.3 | 1 | Chemie (6P8) | |||
| 3 | C (A) | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 1 | Chemie (DIO) | |||
| 4 | D (A) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A: 616 - 910 (UniProt: P54753)
| PDB | External Database | Details |
|---|---|---|
| Gly 613 | - | expression tag |
| Ser 614 | - | expression tag |
| Ser 615 | - | expression tag |
| Pro 899 | Ala 899 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33765.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 366.4 | |
| All* | Total formula weight | 34132.1 |
