5L6P

EphB3 kinase domain covalently bound to an irreversible inhibitor (compound 6)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue 6P8 A 1001

Chain	Residue
A	ALA663
A	LYS665
A	THR711
A	GLU712
A	MET714
A	CYS717
A	LEU765
A	SER775
A	ASP776

---

site_id	AC2
Number of Residues	6
Details	binding site for residue DIO A 1002

Chain	Residue
A	MET686
A	PHE689
A	TYR754
A	HIS756
A	VAL774
A	PHE777

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGAGEFGEVCrGrlkqpgrrevf.......VAIK

Chain	Residue	Details
A	ILE639-LYS665

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLAARNILV

Chain	Residue	Details
A	TYR754-VAL766

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	263
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---