5L36

Crystal Structure of a human FasL mutant in complex with human DcR3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Tumor necrosis factor receptor superfamily member 6B	polymer	174	19044.2	1	UniProt (O95407) Pfam (PF00020)	Homo sapiens (Human)	Decoy receptor 3,DcR3,Decoy receptor for Fas ligand,M68
2	B (A)	Tumor necrosis factor ligand superfamily member 6	polymer	153	17449.2	1	UniProt (P48023) Pfam (PF00229)	Homo sapiens (Human)	Apoptosis antigen ligand,APTL,CD95 ligand,CD95-L,Fas antigen ligand,FasL
3	C (B)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
4	D (A)	water	water		18.0	3	Chemie (HOH)

Sequence modifications

B: 30 - 195 (UniProt: O95407)

PDB	External Database	Details
Thr 196	-	expression tag
Gly 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag

A: 130 - 281 (UniProt: P48023)

PDB	External Database	Details
Met 129	-	initiating methionine
His 164	Asp 164	conflict
Glu 165	Thr 165	conflict
Leu 166	Tyr 166	conflict
Leu 168	Ile 168	conflict
Ala 169	Val 169	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	36493.4
Non-Polymers*	Number of molecules	1
	Total formula weight	23.0
All*	Total formula weight	36516.4

*Water molecules are not included.