5L1G

AMPA subtype ionotropic glutamate receptor GluA2 in complex with GYKI-Br

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutamate receptor 2	polymer	803	89805.7	4	UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	A, B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
3	A, B, C, D	(8R)-5-(4-amino-3-bromophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide	non-polymer		431.3	5	Chemie (GYB)

Sequence modifications

A, B, C, D: 10 - 544 (UniProt: P19491)

PDB	External Database	Details
Glu 241	Asn 256	engineered mutation
-	Val 397	deletion
-	Thr 398	deletion
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
-	Gly 405	deletion
Asp 385	Asn 406	engineered mutation
Gln 392	Asn 413	engineered mutation

A, B, C, D: 567 - 826 (UniProt: P19491)

PDB	External Database	Details
Asp 564	-	linker
Thr 565	-	linker
Asp 566	-	linker
Ala 589	Cys 610	engineered mutation
Gly 827	-	cloning artifact
Leu 828	-	cloning artifact
Val 829	-	cloning artifact
Pro 830	-	cloning artifact
Arg 831	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	359222.9
Non-Polymers*	Number of molecules	9
	Total formula weight	3041.2
All*	Total formula weight	362264.2

*Water molecules are not included.