5L1G
AMPA subtype ionotropic glutamate receptor GluA2 in complex with GYKI-Br
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Glutamate receptor 2 | polymer | 803 | 89805.7 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | A, B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 3 | A, B, C, D | (8R)-5-(4-amino-3-bromophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide | non-polymer | 431.3 | 5 | Chemie (GYB) |
Sequence modifications
A, B, C, D: 10 - 544 (UniProt: P19491)
A, B, C, D: 567 - 826 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Glu 241 | Asn 256 | engineered mutation |
| - | Val 397 | deletion |
| - | Thr 398 | deletion |
| - | Leu 402 | deletion |
| - | Pro 403 | deletion |
| - | Ser 404 | deletion |
| - | Gly 405 | deletion |
| Asp 385 | Asn 406 | engineered mutation |
| Gln 392 | Asn 413 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asp 564 | - | linker |
| Thr 565 | - | linker |
| Asp 566 | - | linker |
| Ala 589 | Cys 610 | engineered mutation |
| Gly 827 | - | cloning artifact |
| Leu 828 | - | cloning artifact |
| Val 829 | - | cloning artifact |
| Pro 830 | - | cloning artifact |
| Arg 831 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 359222.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 3041.2 | |
| All* | Total formula weight | 362264.2 |
