5L1G
AMPA subtype ionotropic glutamate receptor GluA2 in complex with GYKI-Br
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0038023 | molecular_function | signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0038023 | molecular_function | signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0038023 | molecular_function | signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0038023 | molecular_function | signaling receptor activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | ILE529-THR568 | |
| A | LEU596-TYR616 | |
| B | ILE529-THR568 | |
| B | LEU596-TYR616 | |
| C | ILE529-THR568 | |
| C | LEU596-TYR616 | |
| D | ILE529-THR568 | |
| D | LEU596-TYR616 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | INTRAMEM: Helical; Pore-forming |
| Chain | Residue | Details |
| A | PHE571-GLN586 | |
| B | PHE571-GLN586 | |
| C | PHE571-GLN586 | |
| D | PHE571-GLN586 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | INTRAMEM: |
| Chain | Residue | Details |
| A | GLN587-ALA589 | |
| B | GLN587-ALA589 | |
| C | GLN587-ALA589 | |
| D | GLN587-ALA589 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | ASP590-SER595 | |
| B | ASP590-SER595 | |
| C | ASP590-SER595 | |
| D | ASP590-SER595 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 696 |
| Details | TOPO_DOM: Extracellular |
| Chain | Residue | Details |
| A | THR617-ASN791 | |
| B | THR617-ASN791 | |
| C | THR617-ASN791 | |
| D | THR617-ASN791 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Name=M4 |
| Chain | Residue | Details |
| A | VAL792-ILE812 | |
| B | VAL792-ILE812 | |
| C | VAL792-ILE812 | |
| D | VAL792-ILE812 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO |
| Chain | Residue | Details |
| A | THR655 | |
| A | GLU705 | |
| B | VAL484 | |
| B | GLU486 | |
| B | PHE491 | |
| B | SER654 | |
| B | THR655 | |
| B | GLU705 | |
| C | VAL484 | |
| C | GLU486 | |
| C | PHE491 | |
| C | SER654 | |
| C | THR655 | |
| C | GLU705 | |
| D | VAL484 | |
| D | GLU486 | |
| D | PHE491 | |
| D | SER654 | |
| D | THR655 | |
| D | GLU705 | |
| A | VAL484 | |
| A | GLU486 | |
| A | PHE491 | |
| A | SER654 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| D | ILE459 | |
| D | ARG660 | |
| D | LYS752 | |
| B | ARG660 | |
| B | LYS752 | |
| C | ILE459 | |
| C | ARG660 | |
| C | LYS752 | |
| A | ILE459 | |
| A | ARG660 | |
| A | LYS752 | |
| B | ILE459 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ILE633 | |
| B | ILE633 | |
| C | ILE633 | |
| D | ILE633 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293 |
| Chain | Residue | Details |
| A | SER662 | |
| B | SER662 | |
| C | SER662 | |
| D | SER662 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293 |
| Chain | Residue | Details |
| A | SER696 | |
| B | SER696 | |
| C | SER696 | |
| D | SER696 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| C | ALA589 | |
| C | CYS815 | |
| D | ALA589 | |
| D | CYS815 | |
| A | ALA589 | |
| A | CYS815 | |
| B | ALA589 | |
| B | CYS815 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873 |
| Chain | Residue | Details |
| A | GLU241 | |
| B | GLU241 | |
| C | GLU241 | |
| D | GLU241 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ASN355 | |
| B | ASN355 | |
| C | ASN355 | |
| D | ASN355 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | GLU391 | |
| C | THR398 | |
| D | GLU391 | |
| D | THR398 | |
| A | GLU391 | |
| A | THR398 | |
| B | GLU391 | |
| B | THR398 |
