5L0H
Human metavinculin MVt cardiomyopathy-associated mutant R975W (residues 959-1134) in complex with PIP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vinculin | polymer | 176 | 19648.7 | 1 | UniProt (P18206) Pfam (PF01044) | Homo sapiens (Human) | Metavinculin,MV |
| 2 | B (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 3 | C (A) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 1 | Chemie (PIO) | |||
| 4 | D, E (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 5 | F (A) | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 959 - 1134 (UniProt: P18206)
| PDB | External Database | Details |
|---|---|---|
| Trp 975 | Arg 975 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19648.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1042.6 | |
| All* | Total formula weight | 20691.3 |
