5KZV
Crystal structure of the xenopus Smoothened cysteine-rich domain (CRD) in complex with 20(S)-hydroxycholesterol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Smoothened | polymer | 127 | 13991.1 | 1 | UniProt (Q98SW5) Pfam (PF01392) | Xenopus laevis (African clawed frog) | |
| 2 | B (A) | (3alpha,8alpha)-cholest-5-ene-3,20-diol | non-polymer | 402.7 | 1 | Chemie (HCD) PubChem (21968531) PubChem (24774748) PubChem (24779600) PubChem (18665022) PubChem (121935) PubChem (46781746) PubChem (46783726) PubChem (50990014) PubChem (54592389) PubChem (440711) PubChem (69762669) PubChem (71075801) PubChem (53372932) PubChem (66764710) PubChem (90336420) PubChem (71773908) PubChem (90213452) PubChem (3367711) PubChem (6102286) PubChem (129371963) PubChem (118914333) PubChem (121427035) PubChem (71168116) PubChem (124512253) PubChem (125136629) PubChem (126968705) PubChem (129320917) PubChem (129715638) PubChem (131698563) PubChem (144120370) PubChem (146159081) PubChem (166624778) PubChem (171035505) PubChem (175866567) | |||
| 3 | C (A) | water | water | 18.0 | 235 | Chemie (HOH) |
Sequence modifications
A: 35 - 154 (UniProt: Q98SW5)
| PDB | External Database | Details |
|---|---|---|
| Ala 28 | - | expression tag |
| Met 29 | - | expression tag |
| Ala 30 | - | expression tag |
| Asp 31 | - | expression tag |
| Ile 32 | - | expression tag |
| Gly 33 | - | expression tag |
| Ser 34 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13991.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 402.7 | |
| All* | Total formula weight | 14393.7 |
