5KZQ

Metabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Metabotropic glutamate receptor 2	polymer	570	63310.6	1	UniProt (Q14416) Pfam (PF01094) Pfam (PF07562)	Homo sapiens (Human)	mGluR2
2	B (A)	(1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid	non-polymer		359.3	1	Chemie (6YS)
3	C (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
4	D (A)	water	water		18.0	7	Chemie (HOH)

Sequence modifications

A: 1 - 564 (UniProt: Q14416)

PDB	External Database	Details
Glu 563	Trp 563	conflict
His 565	-	expression tag
His 566	-	expression tag
His 567	-	expression tag
His 568	-	expression tag
His 569	-	expression tag
His 570	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	63310.6
Non-Polymers*	Number of molecules	2
	Total formula weight	580.6
All*	Total formula weight	63891.1

*Water molecules are not included.