5KXI
X-ray structure of the human Alpha4Beta2 nicotinic receptor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | Neuronal acetylcholine receptor subunit alpha-4 | polymer | 386 | 44862.4 | 2 | UniProt (P43681) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (Human) | |
2 | B, C, E | Neuronal acetylcholine receptor subunit beta-2 | polymer | 403 | 46748.9 | 3 | UniProt (P17787) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (Human) | |
3 | A, B, C, D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
4 | A, D | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE | non-polymer | 162.2 | 2 | Chemie (NCT) | |||
5 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
6 | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 338 (UniProt: P43681)
A, D: 345 - 386 (UniProt: P43681)
B, C, E: 1 - 330 (UniProt: P17787)
B, C, E: 337 - 393 (UniProt: P17787)
A, D: 345 - 386 (UniProt: P43681)
PDB | External Database | Details |
---|---|---|
Asp 339 | - | linker |
Thr 340 | - | linker |
Asp 341 | - | linker |
Phe 342 | - | linker |
Glu 343 | - | linker |
Arg 344 | - | linker |
B, C, E: 337 - 393 (UniProt: P17787)
PDB | External Database | Details |
---|---|---|
Asp 331 | - | linker |
Asp 332 | - | linker |
Asp 333 | - | linker |
Gln 334 | - | linker |
Glu 335 | - | linker |
Arg 336 | - | linker |
Ser 394 | - | expression tag |
Ala 395 | - | expression tag |
Trp 396 | - | expression tag |
Ser 397 | - | expression tag |
His 398 | - | expression tag |
Pro 399 | - | expression tag |
Gln 400 | - | expression tag |
Phe 401 | - | expression tag |
Glu 402 | - | expression tag |
Lys 403 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 229971.3 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1453.5 | |
All* | Total formula weight | 231424.8 |