5KXI

X-ray structure of the human Alpha4Beta2 nicotinic receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Neuronal acetylcholine receptor subunit alpha-4	polymer	386	44862.4	2	UniProt (P43681) Pfam (PF02931) Pfam (PF02932)	Homo sapiens (Human)
2	B, C, E (B, C, E)	Neuronal acetylcholine receptor subunit beta-2	polymer	403	46748.9	3	UniProt (P17787) Pfam (PF02931) Pfam (PF02932)	Homo sapiens (Human)
3	F, I, J, K, M (A, B, C, D, E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
4	G, L (A, D)	(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE	non-polymer		162.2	2	Chemie (NCT)
5	H (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6	N, O, P, Q, R (A, B, C, D, E)	water	water		18.0	5	Chemie (HOH)

Sequence modifications

A, D: 1 - 338 (UniProt: P43681)
A, D: 345 - 386 (UniProt: P43681)

PDB	External Database	Details
Asp 339	-	linker
Thr 340	-	linker
Asp 341	-	linker
Phe 342	-	linker
Glu 343	-	linker
Arg 344	-	linker

B, C, E: 1 - 330 (UniProt: P17787)
B, C, E: 337 - 393 (UniProt: P17787)

PDB	External Database	Details
Asp 331	-	linker
Asp 332	-	linker
Asp 333	-	linker
Gln 334	-	linker
Glu 335	-	linker
Arg 336	-	linker
Ser 394	-	expression tag
Ala 395	-	expression tag
Trp 396	-	expression tag
Ser 397	-	expression tag
His 398	-	expression tag
Pro 399	-	expression tag
Gln 400	-	expression tag
Phe 401	-	expression tag
Glu 402	-	expression tag
Lys 403	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	229971.3
Non-Polymers*	Number of molecules	8
	Total formula weight	1453.5
All*	Total formula weight	231424.8

*Water molecules are not included.