5KX5
Crystal structure of tubulin-stathmin-TTL-Compound 11 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Tubulin alpha chain | polymer | 451 | 50188.4 | 2 | UniProt (D0VWZ0) Pfam (PF00091) Pfam (PF03953) In PDB | Ovis aries (Sheep) | |
2 | B, D | Tubulin beta chain | polymer | 445 | 49969.8 | 2 | UniProt (D0VWY9) Pfam (PF00091) Pfam (PF03953) In PDB | Ovis aries (Sheep) | |
3 | E | Stathmin-4 | polymer | 143 | 16851.1 | 1 | UniProt (P63043) Pfam (PF00836) In PDB | Rattus norvegicus (Rat) | Stathmin-like protein B3,RB3 |
4 | F | TTL protein | polymer | 384 | 44378.5 | 1 | UniProt (E1BQ43) In PDB | Gallus gallus (Chicken) | |
5 | A, C | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
6 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
7 | A, B, C, E | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
8 | B, D | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
9 | B, D | (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[[(2~{S},3~{S})-2-[[(2~{R})-1,2-dimethylpyrrolidin-2-yl]carbonylamino]-3-methyl-pentanoyl]-methyl-amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-aminophenyl)-2-methyl-pentanoic acid | non-polymer | 743.0 | 2 | Chemie (6YK) | |||
10 | F | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
11 | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
E: 5 - 145 (UniProt: P63043)
F: 1 - 378 (UniProt: E1BQ43)
PDB | External Database | Details |
---|---|---|
Met 3 | - | initiating methionine |
Ala 4 | - | expression tag |
Ala 14 | Cys 85 | conflict |
Trp 20 | Phe 91 | conflict |
PDB | External Database | Details |
---|---|---|
His 379 | - | expression tag |
His 380 | - | expression tag |
His 381 | - | expression tag |
His 382 | - | expression tag |
His 383 | - | expression tag |
His 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 261546.1 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 4152.0 | |
All* | Total formula weight | 265698.1 |