5KVU
Crystal structure of isocitrate dehydrogenase-2 in complex with NADP(+) from Mycobacterium tuberculosis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Isocitrate dehydrogenase | polymer | 745 | 82650.9 | 4 | UniProt (O53611) Pfam (PF03971) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Probable isocitrate dehydrogenase [NADP] Icd2 (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) |
| 2 | E, H, L, Q (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 3 | F (A) | D-MALATE | non-polymer | 134.1 | 1 | Chemie (MLT) | |||
| 4 | G, J, K, O, P... (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 5 | I, R (B, D) | MALONIC ACID | non-polymer | 104.1 | 2 | Chemie (MLA) | |||
| 6 | M (C) | SUCCINIC ACID | non-polymer | 118.1 | 1 | Chemie (SIN) | |||
| 7 | N, S (C, D) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 8 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 423 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 330603.6 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3990.5 | |
| All* | Total formula weight | 334594.1 |
