5KUH

GluK2EM with LY466195

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Glutamate receptor ionotropic, kainate 2	polymer	757	85526.1	4	UniProt (P42260) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Rat)	GluK2, Glutamate receptor 6, GluR6,GluK2, Glutamate receptor 6, GluR6
2	E, F, G, H (A, B, C, D)	(3S,4aR,6S,8aR)-6-{[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl}decahydroisoquinoline-3-carboxylic acid	non-polymer		346.4	4	Chemie (LY5)

Sequence modifications

A, B, C, D: 1 - 513 (UniProt: P42260)

PDB	External Database	Details
Thr 487	Ala 518	engineered mutation

A, B, C, D: 636 - 877 (UniProt: P42260)

PDB	External Database	Details
Gly 516	-	linker
Thr 517	-	linker
Ser 658	Ala 689	engineered mutation
Ser 690	Asn 721	engineered mutation
Leu 704	Phe 735	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	342104.4
Non-Polymers*	Number of molecules	4
	Total formula weight	1385.5
All*	Total formula weight	343489.9

*Water molecules are not included.