5KUH
GluK2EM with LY466195
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Glutamate receptor ionotropic, kainate 2 | polymer | 757 | 85526.1 | 4 | UniProt (P42260) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluK2, Glutamate receptor 6, GluR6,GluK2, Glutamate receptor 6, GluR6 |
| 2 | A, B, C, D | (3S,4aR,6S,8aR)-6-{[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl}decahydroisoquinoline-3-carboxylic acid | non-polymer | 346.4 | 4 | Chemie (LY5) |
Sequence modifications
A, B, C, D: 1 - 513 (UniProt: P42260)
A, B, C, D: 636 - 877 (UniProt: P42260)
| PDB | External Database | Details |
|---|---|---|
| Thr 487 | Ala 518 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 516 | - | linker |
| Thr 517 | - | linker |
| Ser 658 | Ala 689 | engineered mutation |
| Ser 690 | Asn 721 | engineered mutation |
| Leu 704 | Phe 735 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 342104.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1385.5 | |
| All* | Total formula weight | 343489.9 |
