5KUH

GluK2EM with LY466195

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue LY5 A 901

Chain	Residue
A	PRO485
A	LEU486
A	THR487
A	GLY657
A	SER658
A	THR659
A	MET706
A	GLU707

---

site_id	AC2
Number of Residues	8
Details	binding site for residue LY5 B 901

Chain	Residue
B	LEU486
B	THR487
B	GLY657
B	SER658
B	THR659
B	MET706
B	GLU707
B	PRO485

---

site_id	AC3
Number of Residues	8
Details	binding site for residue LY5 C 901

Chain	Residue
C	PRO485
C	LEU486
C	THR487
C	GLY657
C	SER658
C	THR659
C	MET706
C	GLU707

---

site_id	AC4
Number of Residues	8
Details	binding site for residue LY5 D 901

Chain	Residue
D	PRO485
D	LEU486
D	THR487
D	GLY657
D	SER658
D	THR659
D	MET706
D	GLU707

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE789-GLY809
B	ILE789-GLY809
C	ILE789-GLY809
D	ILE789-GLY809

---

site_id	SWS_FT_FI2
Number of Residues	268
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	GLU810-ALA877
B	GLU810-ALA877
C	GLU810-ALA877
D	GLU810-ALA877

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:15721240, ECO:0000269|PubMed:17115050, ECO:0007744|PDB:1S50, ECO:0007744|PDB:1S7Y, ECO:0007744|PDB:2I0B, ECO:0007744|PDB:2I0C

Chain	Residue	Details
C	PRO485
C	ARG492
C	SER658
C	GLU707
D	PRO485
D	ARG492
D	SER658
D	GLU707
A	PRO485
A	ARG492
A	SER658
A	GLU707
B	PRO485
B	ARG492
B	SER658
B	GLU707

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q13002

Chain	Residue	Details
A	SER815
A	SER837
B	SER815
B	SER837
C	SER815
C	SER837
D	SER815
D	SER837

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21791290

Chain	Residue	Details
A	ASN36
A	ASN347
A	ASN381
B	ASN36
B	ASN347
B	ASN381
C	ASN36
C	ASN347
C	ASN381
D	ASN36
D	ASN347
D	ASN381

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN244
B	ASN42
B	ASN399
C	ASN244
C	ASN399
D	ASN42
D	ASN244
D	ASN399
B	ASN244
C	ASN42
A	ASN42
A	ASN399

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15677325

Chain	Residue	Details
A	ASN392
A	ASN720
B	ASN392
B	ASN720
C	ASN392
C	ASN720
D	ASN392
D	ASN720

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000269|PubMed:17486098

Chain	Residue	Details
A	LYS855
B	LYS855
C	LYS855
D	LYS855

---