5KTU
Crystal structure of the bromodomain of human CREBBP bound to pyrazolopiperidine scaffold
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | CREB-binding protein | polymer | 118 | 13992.0 | 2 | UniProt (Q92793) Pfam (PF00439) In PDB | Homo sapiens (Human) | |
| 2 | A | 1-(3-phenylazanyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)ethanone | non-polymer | 256.3 | 1 | Chemie (6XB) | |||
| 3 | B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 4 | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
A, B: 1082 - 1197 (UniProt: Q92793)
| PDB | External Database | Details |
|---|---|---|
| Gly 1080 | - | expression tag |
| Ser 1081 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27984.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 334.4 | |
| All* | Total formula weight | 28318.5 |
